DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and prkcq

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_009298659.1	Gene:	prkcq / 555521	ZFINID:	ZDB-GENE-041210-195	Length:	719	Species:	Danio rerio

Alignment Length:	330	Identity:	150/330 - (45%)
Similarity:	217/330 - (65%)	Gaps:	9/330 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 KVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNH 323
            |.|:::|...|:||||:||||.|...|.:.:.:|:|.|||:|::..|:|..|:.|.|||. :.:|
Zfish   386 KFTIDSFILHKMLGKGSFGKVFLAELKGSGQFFAVKALKKDVVLMDDDVECTMVERRVLSLAWDH 450

  Fly   324 PFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYR 388
            |||..|..:|||.:.|.|||:|:|||:|.:|:.....|...|:.||.||||..|.:|||:||:||
Zfish   451 PFLTHLYCTFQTKENLFFVMEYLNGGDLMFHIQTCHRFDLPRSTFYAAEIICGLQFLHSKGIVYR 515

  Fly   389 DLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVV 453
            ||||:|:|||.|||||:||||:|||:|.....|.||||||:|:|||:|....||.:||||..||:
Zfish   516 DLKLDNILLDTDGHIKIADFGMCKENIIGEARTCTFCGTPDYIAPEILLGQKYGTSVDWWSFGVL 580

  Fly   454 MYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVK-EI 517
            :|||:.|:.||:..|.:.||..|..::..:||.:|.:|:::|..|..::|::|||     || .|
Zfish   581 LYEMLIGQSPFHGHDEEELFQSIRTDDPCYPRWLTRDARDILVKLFVREPERRLG-----VKGNI 640

  Fly   518 QAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLF 582
            :.||||...:|:.|..:::.|||||.|.|..|...|||||..|...|:..|..  :.:..::.:|
Zfish   641 RQHPFFRETDWSALEERQVEPPFKPTVKSANDCSNFDKEFINEKPRLSVTDRM--MINSMDQSMF 703

  Fly   583 PQFSY 587
            ..||:
Zfish   704 ENFSF 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	125/258 (48%)
		STKc_PKB	270..590	CDD:270723	147/320 (46%)
prkcq	XP_009298659.1	C1_1	166..218	CDD:278556
		C1_1	238..290	CDD:278556
		STKc_nPKC_theta	386..716	CDD:270770	150/330 (45%)
		S_TKc	392..646	CDD:214567	125/258 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910