DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and prkci

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001012707.1	Gene:	prkci / 503517	XenbaseID:	XB-GENE-481945	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	357	Identity:	154/357 - (43%)
Similarity:	229/357 - (64%)	Gaps:	21/357 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 PSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKA 287
            |..|.::..|     .|::.:......|.|.:|.|     |::|:.::|:|:|::.||:|.|.|.
Frog   213 PRSQDNLDQV-----GEEKEAMNSRESGKTPSSLG-----LQDFDLMRVIGRGSYAKVLLVRLKK 267

  Fly   288 TAKLYAIKILKKEVIIQKDEVAHTLTESRVL-KSTNHPFLISLKYSFQTNDRLCFVMQYVNGGEL 351
            |.::||:|::|||::...:::....||..|. :::|||||:.|...|||..||.||::|||||:|
Frog   268 TERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDL 332

  Fly   352 FWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDIT 416
            .:|:..:|...|:..|||.|||..||.|||.:|||||||||:|:|||.:||||:.|:|:|||.:.
Frog   333 MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLR 397

  Fly   417 YGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF------YNRD---HDVL 472
            .|.||.||||||.|:|||:|...|||.:||||..||:|:||:.||.||      .|.|   .|.|
Frog   398 PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDFL 462

  Fly   473 FTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLG-GGKDDVKEIQAHPFFASINWTDLVLKKI 536
            |.:||.::::.||:::.:|.::|...|.||||.||| ..:....:||.|.||.:::|..:..|::
Frog   463 FQVILEKQIRIPRSLSVKAASVLKSFLNKDPKDRLGCHPQTGFADIQGHQFFRNVDWDLMEQKQV 527

  Fly   537 PPPFKPQVTSDTDTRYFDKEFTGESVELTPPD 568
            .|||||.::.:.....||.:||.|.|:|||.|
Frog   528 VPPFKPNISGEFGLDNFDAQFTNEPVQLTPDD 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	126/267 (47%)
		STKc_PKB	270..590	CDD:270723	144/310 (46%)
prkci	NP_001012707.1	PB1_aPKC	19..101	CDD:99725
		C1_1	134..186	CDD:278556
		STKc_aPKC_iota	225..588	CDD:270769	150/340 (44%)
		S_TKc	246..514	CDD:214567	126/267 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010