DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Rps6ka3

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_017457618.1	Gene:	Rps6ka3 / 501560	RGDID:	1563860	Length:	759	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	158/379 - (41%)
Similarity:	227/379 - (59%)	Gaps:	21/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 IAEDEL---SEQFSVQGTTCN---SSGVKKVTLENFEFLKVLGKGTFGKVILCRE---KATAKLY 292
            :.|:|:   :|:.|::.....   ..|.:|.....||.|||||:|:||||.|.::   ....:||
  Rat    52 MGEEEINPQTEEGSIKEIAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLY 116

  Fly   293 AIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSH 357
            |:|:|||..:..:|.| .|..|..:|...||||::.|.|:|||..:|..::.::.||:||..||.
  Rat   117 AMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSK 180

  Fly   358 ERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTK 422
            |.:|||:..:||.||:..||.:|||.||||||||.||:|||::||||:.||||.||.|.:.:...
  Rat   181 EVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAY 245

  Fly   423 TFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNI 487
            :||||.||:||||::...:.|:.|||..||:|:||:.|.|||..:|.....|:||..::..|:.:
  Rat   246 SFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFL 310

  Fly   488 TDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRY 552
            :.||::||..|..::|..|||.|.|.|:||:.|.||::|:|..|..::|.|||||......||.|
  Rat   311 SPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFY 375

  Fly   553 FDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSY-------QGDMASTLGTSS 599
            ||.|||.:    ||.|..|...|.....||..||:       :.....|:|..|
  Rat   376 FDPEFTAK----TPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHS 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	121/259 (47%)
		STKc_PKB	270..590	CDD:270723	146/329 (44%)
Rps6ka3	XP_017457618.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910