DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and akt2l

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_021334818.1	Gene:	akt2l / 403146	ZFINID:	ZDB-GENE-040121-5	Length:	625	Species:	Danio rerio

Alignment Length:	473	Identity:	284/473 - (60%)
Similarity:	359/473 - (75%)	Gaps:	32/473 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 QTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKP--ADSASTPSDFLLNNFTVRGCQIM 166
            :..|||||||:||||:||.||.|||:|.|||..:||:.||  .|.:..|    ||||:|..||:|
Zfish     3 ELSVVKEGWLLKRGEYIKTWRPRYFILKSDGSFIGYKEKPELTDQSCAP----LNNFSVEECQLM 63

  Fly   167 TVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRL--IDVGEVA----MTPSE 225
            ..:||:|.||:||.|||||||||||.|:|..||.:|..||:.|::.|  .||.|..    .:||:
Zfish    64 KTERPRPNTFMIRCLQWTTVIERTFHVDSSDERDEWMRAIQMVANGLQARDVDEPMEIKYSSPSD 128

  Fly   226 QTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAK 290
            .  :.|::|                  |.|....:||:.:|::||:|||||||||||.||||:..
Zfish   129 A--LEDMEM------------------CLSKSSSRVTMNDFDYLKLLGKGTFGKVILVREKASGM 173

  Fly   291 LYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHL 355
            .||:|||:|||||.|||||||:||||||::|.||||.:|||:|||:|||||||:|.||||||:||
Zfish   174 YYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTTLKYAFQTHDRLCFVMEYANGGELFFHL 238

  Fly   356 SHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRT 420
            |.||:|:|||.|||||||:|||.|.|||.::||.||||||:||.|||||:.|||||||.||...|
Zfish   239 SRERVFSEDRARFYGAEIVSALDYPHSQNVVYRHLKLENLMLDNDGHIKITDFGLCKEGITDEAT 303

  Fly   421 TKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPR 485
            .:||||||||||||||:|||||:||||||.|||||||:|||||||::||:.||..|::||::|||
Zfish   304 MRTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYSQDHERLFEQIVMEEIRFPR 368

  Fly   486 NITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDT 550
            :::..|:.||.|||.|:||:|||||.||.:::..|.||:.:.|.|::.||:.|||||||||:|||
Zfish   369 SLSTHARALLTGLLRKEPKQRLGGGPDDARDVMMHKFFSGVQWDDVLQKKLLPPFKPQVTSETDT 433

  Fly   551 RYFDKEFTGESVELTPPD 568
            ||||.|||.:|:.:||||
Zfish   434 RYFDDEFTAQSITVTPPD 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	63/112 (56%)
		PH	107..211	CDD:278594	62/105 (59%)
		S_TKc	266..523	CDD:214567	180/256 (70%)
		STKc_PKB	270..590	CDD:270723	208/299 (70%)
akt2l	XP_021334818.1	PH_PKB	4..111	CDD:269947	62/110 (56%)
		PKc_like	153..462	CDD:328722	208/299 (70%)
		PKc_like	<423..551	CDD:328722	22/29 (76%)
		S_TK_X	553..621	CDD:214529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I589
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	623	1.000	Inparanoid score	I846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm24506
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.970