DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and prkcbb

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_957272.1	Gene:	prkcbb / 393953	ZFINID:	ZDB-GENE-040426-1178	Length:	670	Species:	Danio rerio

Alignment Length:	465	Identity:	181/465 - (38%)
Similarity:	264/465 - (56%)	Gaps:	55/465 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 TVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQ------QWTEAIRN--VSSRLID 215
            |::.|...|.:  :.|||.::              ||:.:|:      .|....||  :.|....
Zfish   213 TIKCCLNPTWN--ETFTFNLK--------------ESDKDRRLSVEIWDWDLTSRNDFMGSLSFG 261

  Fly   216 VGEV---------AMTPSEQTDMTDVDMATIAE---DELSEQF--------SVQGTTCN------ 254
            :.|:         .:...|:.:..:|.:....|   :||.::|        ...|::.|
Zfish   262 ISELQKQGVDGWFKLLSQEEGEYFNVPVPPEGEEGNEELRQKFERAKIGPSKTDGSSSNAISKFD 326

  Fly   255 SSGVK-KVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVL 318
            |:|.: ::.|.:|.||.|||||:||||:|...|...:|:|||||||:|:||.|:|..|:.|.|||
Zfish   327 SNGNRDRMKLSDFNFLMVLGKGSFGKVMLAERKGADELFAIKILKKDVVIQDDDVECTMVEKRVL 391

  Fly   319 K-STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHS 382
            . |...|||..|...|||.|||.|||:|:|||:|.:|:.....|.|....||.|||...|.:|||
Zfish   392 ALSGKPPFLTQLHSCFQTMDRLYFVMEYINGGDLMYHIQQVGKFKEPHAVFYAAEIAIGLFFLHS 456

  Fly   383 QGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDW 447
            :|:|||||||:|::||.:||||:||||:|||::..|.|||||||||:|:|||::....||::|||
Zfish   457 KGVIYRDLKLDNVMLDAEGHIKIADFGMCKENMLDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDW 521

  Fly   448 WGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKD 512
            |..||::|||:.|:.||...|.|.||..|:...|.:|::::.||..:..||:.|.|.||||.|.:
Zfish   522 WAFGVLLYEMLAGQPPFDGEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGCGPE 586

  Fly   513 DVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIA 577
            ..::|:.|.||..::|..|..:::.|||||:... .|...||:.||.....|||||....:....
Zfish   587 GERDIREHGFFRYMDWEKLEHREVQPPFKPKACG-RDAENFDRFFTRHPPVLTPPDQEVIMNLDQ 650

  Fly   578 EEPLFPQFSY 587
            :|  |..||:
Zfish   651 DE--FEGFSF 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	13/62 (21%)
		PH	107..211	CDD:278594	12/59 (20%)
		S_TKc	266..523	CDD:214567	133/257 (52%)
		STKc_PKB	270..590	CDD:270723	153/319 (48%)
prkcbb	NP_957272.1	C1_1	36..88	CDD:278556
		C1_1	101..151	CDD:278556
		C2_PKC_alpha_gamma	158..288	CDD:175992	15/90 (17%)
		STKc_cPKC_beta	338..660	CDD:270767	156/324 (48%)
		S_TKc	339..597	CDD:214567	133/257 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920