DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and akt2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_937789.1	Gene:	akt2 / 378972	ZFINID:	ZDB-GENE-031007-5	Length:	479	Species:	Danio rerio

Alignment Length:	493	Identity:	302/493 - (61%)
Similarity:	376/493 - (76%)	Gaps:	23/493 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 QTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADS-ASTPSDFLLNNFTVRGCQIMT 167
            :..||:||||.||||:||.||.|||:|.|||..:||:.||..| |:.|.   ||||:|..||:|.
Zfish     3 EISVVREGWLHKRGEYIKTWRPRYFILKSDGSFIGYKEKPETSDANQPP---LNNFSVAECQLMK 64

  Fly   168 VDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDV 232
            .:||:|.||:||.|||||||||||.|:|..||::|..||:.|::        .:...|:.:..|:
Zfish    65 TERPRPNTFVIRCLQWTTVIERTFHVDSNSEREEWIRAIQAVAN--------GLKSREEDEPMDI 121

  Fly   233 DMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKIL 297
            :..:..::.|.   .::.....|.  .|||:.:|::||:|||||||||||.|||||...||:|||
Zfish   122 NFGSPGDNSLE---GMEAAITKSR--TKVTMSDFDYLKLLGKGTFGKVILVREKATGMYYAMKIL 181

  Fly   298 KKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFT 362
            :|||||.|||||||:||||||::|.||||.:|||:|||.|||||||:|.||||||:|||.||:||
Zfish   182 RKEVIIAKDEVAHTITESRVLQNTRHPFLTTLKYAFQTRDRLCFVMEYANGGELFFHLSRERVFT 246

  Fly   363 EDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGT 427
            |||.|||||||:|||.||||:.::|||||||||:||||||||:.|||||||.||...|.||||||
Zfish   247 EDRARFYGAEIVSALEYLHSKDVVYRDLKLENLMLDKDGHIKITDFGLCKEGITNEATMKTFCGT 311

  Fly   428 PEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAK 492
            |||||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:||::||||::.|||
Zfish   312 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRNLSPEAK 376

  Fly   493 NLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEF 557
            .||||||.||||:|||||.:|.||:..|.||.::||.|::.||:.|||||||||:|||||||.||
Zfish   377 ALLAGLLKKDPKQRLGGGPEDAKEVMTHKFFNNMNWQDVLQKKLVPPFKPQVTSETDTRYFDDEF 441

  Fly   558 TGESVELTPPDPTGPLGSIAEEP----LFPQFSYQGDM 591
            |.:::.:||||....|.  ||:|    .|.||||...:
Zfish   442 TAQTITVTPPDQYDSLD--AEDPDTRTHFSQFSYSASV 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	62/109 (57%)
		PH	107..211	CDD:278594	62/104 (60%)
		S_TKc	266..523	CDD:214567	194/256 (76%)
		STKc_PKB	270..590	CDD:270723	231/323 (72%)
akt2	NP_937789.1	PH_PKB	4..111	CDD:269947	62/117 (53%)
		PH	6..106	CDD:278594	61/102 (60%)
		S_TKc	150..407	CDD:214567	194/256 (76%)
		STKc_PKB_beta	154..476	CDD:173686	231/323 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I589
eggNOG	1	0.900	-	-		E2759_KOG0690
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48773
Inparanoid	1	1.050	623	1.000	Inparanoid score	I846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm24506
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860