Protein Alignment Akt and Lats1

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001128015.2
• Gene: Lats1 / 308265
• RGDID: 1564085
• Length: 1130
• Species: Rattus norvegicus
• Alignment Length: 719
• Identity: 185/719 - (25%)
• Similarity: 297/719 - (41%)
• Gaps: 216/719 - (30%)

  Fly     9 QRRSTVVASAP-APGSAS--RIPES---PTTTGSNI----INIIYSQSTHP-------NSSPTSG 56
            |..|.:.|..| ||.|.|  .:|.:   |.....|:    ||:...|:|.|       .|||:||
  Rat   384 QSPSALQAGGPAAPPSFSNGNVPPTMMVPNRNSHNMELYNINVPGLQTTWPQSSSAPVQSSPSSG 448

  Fly    57 SAEKFSWQQSWPSRTSA--APTHDSGTMSINTTFDLSSPSVTSGHALTEQ--TQVVKEGWLMK-- 115
            . |..:||.:.|.|:::  .|.....:.|.|     |.||.|:..|:|..  .|.||...::|
  Rat   449 H-EIPTWQPNIPVRSNSFNNPLGSRASHSAN-----SQPSATTVTAITPAPIQQPVKSMRVLKPE 507

  Fly   116 -----RGEHIKNWRQR--------------------------------------YFVLHSDGRLM 137
                 ...| .:|..:                                      ..:||....:.
  Rat   508 LQTALAPTH-PSWMPQPVQTVQPSPFSEGAASNVPVIPPVAEAPSYQGPPPPYPKHLLHQTPSVP 571

  Fly   138 GYRS--------KPADSASTPSDFLLNN---------------FTV---------RGCQIMTVDR 170
            .|.|        :|:.:....|:..|::               .||         |..:|.:..
  Rat   572 PYESASKPCKDDQPSSAKEEDSEKSLDSVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSYS- 635

  Fly   171 PKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMA 235
            |:.|.|.               :|..:|     ..:::...||....::      :.:|..|.::
  Rat   636 PQAFKFF---------------MEQHVE-----NVLKSHQQRLHRKKQL------ENEMMRVGLS 674

  Fly   236 TIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKV--LGKGTFGKVILCREKATAKLYAIKILK 298
            ..|:|::.:....:.:  |...:|:..::...|:|:  ||.|.||:|.|.|:..|..|||.|.|:
  Rat   675 QDAQDQMRKMLCQKES--NYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLR 737

  Fly   299 KEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTE 363
            |:.::.:::|||...|..:|...::.:::.|.||||..|.|.|||.|:.||::...|....||.|
  Rat   738 KKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPE 802

  Fly   364 DRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLC----------------- 411
            :..|||.||:..|:..:|..|.|:||:|.:|:|:|:|||||:.|||||
  Rat   803 NLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDH 867

  Fly   412 -KED-----ITYGRTTKTFC------------------------GTPEYLAPEVLDDNDYGQAVD 446
             ::|     ..:|..:...|                        |||.|:|||||....|.|..|
  Rat   868 PRQDSMDFSSEWGDPSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCD 932

  Fly   447 WWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKF----------PR-NITDEAKNLLAGLLA 500
            ||..||:::||:.|:.||       |....|..::|.          |: .::.||.:|:. .|.
  Rat   933 WWSVGVILFEMLVGQPPF-------LAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLII-KLC 989

  Fly   501 KDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELT 565
            :.|:.||  ||:...||:|||||.:|:::. .|::....:.|::|..|||..||
  Rat   990 RGPEDRL--GKNGADEIKAHPFFKTIDFSS-DLRQQSASYIPKITHPTDTSNFD----------- 1040

  Fly   566 PPDP 569
            |.||
  Rat  1041 PVDP 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	23/185 (12%)
		STKc_PKB	270..590	CDD:270723	119/360 (33%)
Lats1	NP_001128015.2	UBA_like_SF	103..143	CDD:473871
		PHA03247	<183..590	CDD:223021	46/212 (22%)
		MobB_LATS1	629..704	CDD:439273	14/103 (14%)
		STKc_LATS1	703..1084	CDD:270775	120/364 (33%)