DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and STK32C

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_011537990.1	Gene:	STK32C / 282974	HGNCID:	21332	Length:	504	Species:	Homo sapiens

Alignment Length:	329	Identity:	105/329 - (31%)
Similarity:	169/329 - (51%)	Gaps:	33/329 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 LSEQFSVQGTTCNS-----------SGV----KKVTLENFEFLKVLGKGTFGK-----VILCREK 286
            |:...:.:||...|           .||    |::..::|:.|:.:|||:|||     |.:.:::
Human    67 LASGLAARGTQTQSVLFGEVRLPLDGGVRGARKRMNFDHFQILRAIGKGSFGKPCALQVCIVQKR 131

  Fly   287 ATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGEL 351
            .|.|:||:|.:.|:..|::|||.:...|..:|:...|.||::|.||||..:.:..|:..:.||:|
Human   132 DTEKMYAMKYMNKQQCIERDEVRNVFRELEILQEIEHVFLVNLWYSFQDEEDMFMVVDLLLGGDL 196

  Fly   352 FWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDIT 416
            .:||.....|:||..|.|..|:..||.||..|.||:||:|.:|:|||:.||..:.||.:. ..|.
Human   197 RYHLQQNVQFSEDTVRLYICEMALALDYLRGQHIIHRDVKPDNILLDERGHAHLTDFNIA-TIIK 260

  Fly   417 YGRTTKTFCGTPEYLAPEVLDD-----NDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLI 476
            .|.......||..|:|||:...     ..|...||||..||:.||::.|..|:.....:.:.:|:
Human   261 DGERATALAGTKPYMAPEIFHSFVNGGTGYSFEVDWWSVGVMAYELLRGWRPYDIHSSNAVESLV 325

  Fly   477 LV---EEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPP 538
            .:   ..|::....:.|...||..||..:|:.||    ..::::||.|..|.:.|..|..|::.|
Human   326 QLFSTVSVQYVPTWSKEMVALLRKLLTVNPEHRL----SSLQDVQAAPALAGVLWDHLSEKRVEP 386

  Fly   539 PFKP 542
            .|.|
Human   387 GFVP 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	91/269 (34%)
		STKc_PKB	270..590	CDD:270723	96/286 (34%)
STK32C	XP_011537990.1	STKc_Yank1	105..371	CDD:270730	91/270 (34%)
STK32C	XP_011537990.1	S_TKc	106..366	CDD:214567	88/264 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910