DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Sgk2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_038759.1	Gene:	Sgk2 / 27219	MGIID:	1351318	Length:	367	Species:	Mus musculus

Alignment Length:	330	Identity:	166/330 - (50%)
Similarity:	215/330 - (65%)	Gaps:	7/330 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 NFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRV-LKSTNHPFLIS 328
            :|:||||:|||.:|||:|.:.|:....||:|:|:|:.|::..|..|.:.|..| ||:..||||:.
Mouse    34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHIMAERNVLLKNVRHPFLVG 98

  Fly   329 LKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLE 393
            |:|||||.::|.||:.||||||||:||..||.|.|.|.|||.||:.||:|||||..|||||||.|
Mouse    99 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYTAEVASAIGYLHSLNIIYRDLKPE 163

  Fly   394 NLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMI 458
            |:|||..||:.:.|||||||.:....||.||||||||||||||....|.:|||||..|.|:|||:
Mouse   164 NILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEML 228

  Fly   459 CGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF 523
            .|..||:|.|...::..||.:.::.|...|..|.:||.|||.||.::|| |.|:|..:|:.|.||
Mouse   229 HGLPPFFNTDVAQMYENILHQPLQIPGGRTVAACDLLQGLLHKDQRQRL-GSKEDFLDIKNHMFF 292

  Fly   524 ASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELT---PPDPTGPLGSIAEEPLFPQF 585
            :.|||.||..|::.|||.|.|....|.::||.|||.|:|..:   .||...  .|......|..|
Mouse   293 SPINWDDLYHKRLTPPFNPNVEGPADLKHFDPEFTQEAVSKSIGCTPDTVA--SSSGASSAFLGF 355

  Fly   586 SYQGD 590
            ||..|
Mouse   356 SYAQD 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	137/257 (53%)
		STKc_PKB	270..590	CDD:270723	162/323 (50%)
Sgk2	NP_038759.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		PKc_like	39..359	CDD:389743	162/322 (50%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850