DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Stk32a

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_848864.1	Gene:	Stk32a / 269019	MGIID:	2442403	Length:	398	Species:	Mus musculus

Alignment Length:	292	Identity:	103/292 - (35%)
Similarity:	166/292 - (56%)	Gaps:	19/292 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 VTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPF 325
            |..::||.|:.:|||:||||.:.|:..|.|:||:|.:.|:..::::||.:...|.::::...|||
Mouse    18 VNFDHFEILRAIGKGSFGKVCIVRKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQGLEHPF 82

  Fly   326 LISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDL 390
            |::|.||||..:.:..|:..:.||:|.:||.....|.||..:.:..|:..||.||.||.||:||:
Mouse    83 LVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNVHFQEDTVKLFICELAMALDYLQSQRIIHRDM 147

  Fly   391 KLENLLLDKDGHIKVADFGLC----KEDITYGRTTKTFCGTPEYLAPEVL---DDNDYGQAVDWW 448
            |.:|:|||:.||:.:.||.:.    ||.    |.| |..||..|:|||:.   .:..|..|||||
Mouse   148 KPDNILLDEHGHVHITDFNIAAMLPKET----RIT-TVAGTKPYMAPEMFTSRKETGYSFAVDWW 207

  Fly   449 GTGVVMYEMICGRLPFYNRDHDVLFTLILVEE---VKFPRNITDEAKNLLAGLLAKDPKKRLGGG 510
            ..||..||::.||.|::.|.......::.:.|   |.:|...:.|..:||..||..:|.:|.
Mouse   208 SLGVTAYELLRGRRPYHIRSSTSSKEIVNMFETAIVTYPSAWSQEMVSLLKKLLEPNPDQRF--- 269

  Fly   511 KDDVKEIQAHPFFASINWTDLVLKKIPPPFKP 542
             ..:.:||..|:.:.:||..::.|::.|.|.|
Mouse   270 -SHLTDIQNFPYMSDMNWDAVLQKRLIPGFIP 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	96/266 (36%)
		STKc_PKB	270..590	CDD:270723	99/283 (35%)
Stk32a	NP_848864.1	STKc_Yank1	22..281	CDD:270730	96/267 (36%)
		S_TKc	23..270	CDD:214567	93/255 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..398
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910