DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Prkcz

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_038965237.1	Gene:	Prkcz / 25522	RGDID:	3399	Length:	605	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	157/394 - (39%)
Similarity:	235/394 - (59%)	Gaps:	48/394 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 AMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTC--------------------NSSGVKKVT-- 262
            ::.||::..:.|.:.......|.::..::..|.|                    :|..:|.|.
  Rat   186 SVMPSQEPPVDDKNDGVDLPSEETDGIALHSTWCATARPVAYISSSRKHDNIKDDSEDLKPVIDG 250

  Fly   263 -----------LENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESR 316
                       |::|:.::|:|:|::.||:|.|.|...::||:|::|||::...:::....||..
  Rat   251 VDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKH 315

  Fly   317 VL-KSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYL 380
            |. :::::|||:.|...|||..||..|::|||||:|.:|:..:|...|:..|||.|||..||.:|
  Rat   316 VFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFL 380

  Fly   381 HSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAV 445
            |.:|||||||||:|:|||.|||||:.|:|:|||.:..|.||.||||||.|:|||:|...:||.:|
  Rat   381 HERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSV 445

  Fly   446 DWWGTGVVMYEMICGRLPF----YNRD---HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDP 503
            |||..||:|:||:.||.||    .|.|   .|.||.:||.:.::.||.::.:|.::|.|.|.|||
  Rat   446 DWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDP 510

  Fly   504 KKRLG----GGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVEL 564
            |:|||    .|..|:|   :|.||.||:|..|..|:..|||:||:|.|.....||.:||.|.|:|
  Rat   511 KERLGCRPQTGFSDIK---SHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQL 572

  Fly   565 TPPD 568
            ||.|
  Rat   573 TPDD 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	123/268 (46%)
		STKc_PKB	270..590	CDD:270723	146/311 (47%)
Prkcz	XP_038965237.1	PB1_aPKC	16..98	CDD:99725
		C1_aPKC_zeta	129..183	CDD:410448
		STKc_aPKC_zeta	249..605	CDD:270768	148/331 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920