DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and psk1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_587830.1	Gene:	psk1 / 2539494	PomBaseID:	SPCC4G3.08	Length:	436	Species:	Schizosaccharomyces pombe

Alignment Length:	391	Identity:	141/391 - (36%)
Similarity:	216/391 - (55%)	Gaps:	24/391 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 DVGEVAMTPSEQTDMTDVDMATIAEDEL-SEQFSV--QGTTCNSSGVK-----KVTLENFEFLKV 271
            |..|:..:.|..|..:|:.....|:||. :.:|.|  .|...:|.|..     |:...:|:.|.|
pombe    32 DFEELEASASTITSSSDLKDGKNAKDEKGTVEFKVAAHGDFISSKGDNYVPSGKMRPADFQPLTV 96

  Fly   272 LGKGTFGKVILCREKATAKLYAIKILKK-EVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQT 335
            ||:|::|||:|.::|.|.:|:|.|.||| .::::...:..|..|.::|:...|||:..|.|:||.
pombe    97 LGRGSYGKVLLVKQKNTGRLFAQKQLKKASIVLRAKGLEQTKNERQILEEVRHPFICRLYYAFQD 161

  Fly   336 NDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKD 400
            :|||..::||..|||||.||:.:|:..||...||.||:..||.:||..||:|||||.||.|||.:
pombe   162 HDRLYLILQYAPGGELFSHLAEQRMLPEDVVAFYTAELTLALIHLHKLGIVYRDLKPENCLLDAE 226

  Fly   401 GHIKVADFGLCK--EDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLP 463
            |||.:.||||.|  |:   |...::|.||.||.|||:|.:..|..|||||..|:::::::.|..|
pombe   227 GHILLTDFGLSKVAEN---GADCRSFVGTEEYCAPEILLEQPYDHAVDWWSMGILIFDLLTGSPP 288

  Fly   464 FYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGG-----GKDDVKEIQAHPFF 523
            |...:|..:...|...:...|..:|.:|::::...|.|:||:|||.     |.|.:|:   |..:
pombe   289 FTANNHKRIMEKITRAKPNIPFYVTSDARDIINKFLKKNPKQRLGADGPEKGYDAIKK---HRIY 350

  Fly   524 ASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTP--PDPTGPLGSIAEEPLFPQFS 586
            ..|:|..|..:.:|||..|.:|:......|..|||...:..||  .:..|.|...:....|..|:
pombe   351 RRIDWNKLEKRMLPPPIVPCITNPEAAENFSVEFTKLPLSTTPILHEEFGNLTIGSHSSAFQGFT 415

  Fly   587 Y 587
            |
pombe   416 Y 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	108/264 (41%)
		STKc_PKB	270..590	CDD:270723	125/328 (38%)
psk1	NP_587830.1	S_TKc	91..335	CDD:214567	104/246 (42%)
		STKc_AGC	97..350	CDD:270693	105/258 (41%)
		S_TK_X	351..418	CDD:214529	19/66 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840