DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Akt2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_008757330.1	Gene:	Akt2 / 25233	RGDID:	2082	Length:	496	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	298/478 - (62%)
Similarity:	363/478 - (75%)	Gaps:	19/478 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 EHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFL--LNNFTVRGCQIMTVDRPKPFTFIIRG 180
            |:||.||.|||:|.|||..:||:.:|    ..|...|  ||||:|..||:|..:||:|.||:||.
  Rat    32 EYIKTWRPRYFLLKSDGSFIGYKERP----EAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRC 92

  Fly   181 LQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQ 245
            |||||||||||.|:|..||::|..||:.|::.|...|     |.|  |..|....:.::...||.
  Rat    93 LQWTTVIERTFHVDSPDEREEWIRAIQMVANSLKQRG-----PGE--DAMDYKCGSPSDSSTSEM 150

  Fly   246 FSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAH 310
            ..|    ..|....|||:.:|::||:|||||||||||.|||||.:.||:|||:|||||.||||||
  Rat   151 MEV----AVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAH 211

  Fly   311 TLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIIS 375
            |:||||||::|.||||.:|||:|||:|||||||:|.||||||:|||.||:|||||.|||||||:|
  Rat   212 TVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEDRARFYGAEIVS 276

  Fly   376 ALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDND 440
            ||.||||:.::|||:|||||:||||||||:.|||||||.|:.|.|.|||||||||||||||:|||
  Rat   277 ALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDND 341

  Fly   441 YGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKK 505
            ||:||||||.|||||||:||||||||:||:.||.|||:||::|||.:..|||:||||||.||||:
  Rat   342 YGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLGPEAKSLLAGLLKKDPKQ 406

  Fly   506 RLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPT 570
            |||||..|.||:..|.||.||||.|:|.||:.|||||||||:.||||||.|||.:|:.:||||..
  Rat   407 RLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRY 471

  Fly   571 GPLGSIA--EEPLFPQFSYQGDM 591
            ..|||:.  :...||||||...:
  Rat   472 DSLGSLELDQRTHFPQFSYSASI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	51/97 (53%)
		PH	107..211	CDD:278594	51/94 (54%)
		S_TKc	266..523	CDD:214567	192/256 (75%)
		STKc_PKB	270..590	CDD:270723	232/321 (72%)
Akt2	XP_008757330.1	PH_PKB	32..126	CDD:269947	51/97 (53%)
		PH	35..121	CDD:278594	48/89 (54%)
		S_TKc	167..424	CDD:214567	192/256 (75%)
		STKc_PKB_beta	171..493	CDD:173686	232/321 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	425	1.000	Domainoid score	I591
eggNOG	1	0.900	-	-		E2759_KOG0690
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48773
Inparanoid	1	1.050	627	1.000	Inparanoid score	I817
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm45091
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830