DRSC/TRiP Functional Genomics Resources

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Protein Alignment Akt1 and Akt1

DIOPT Version :9

Sequence 1:NP_732113.3 Gene:Akt1 / 41957 FlyBaseID:FBgn0010379 Length:611 Species:Drosophila melanogaster
Sequence 2:NP_150233.1 Gene:Akt1 / 24185 RGDID:2081 Length:480 Species:Rattus norvegicus


Alignment Length:500 Identity:303/500 - (60%)
Similarity:377/500 - (75%) Gaps:33/500 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   107 VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRP 171
            :||||||.||||:||.||.|||:|.:||..:||:.:|.|.....|.  ||||:|..||:|..:||
  Rat     6 IVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVEQRESP--LNNFSVAQCQLMKTERP 68

  Fly   172 KPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAM-----TPSEQTDMTD 231
            :|.|||||.|||||||||||.||:..||::||.||:.|:..|....|..|     :||:.:...:
  Rat    69 RPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDFRSGSPSDNSGAEE 133

  Fly   232 VDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKI 296
            :::| :|:.:                 .:||:..||:||:|||||||||||.:||||.:.||:||
  Rat   134 MEVA-LAKPK-----------------HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

  Fly   297 LKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIF 361
            ||||||:.||||||||||:|||:::.||||.:|||||||:|||||||:|.||||||:|||.||:|
  Rat   181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF 245

  Fly   362 TEDRTRFYGAEIISALGYLHSQ-GIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFC 425
            :|||.|||||||:|||.||||: .::|||||||||:||||||||:.|||||||.|..|.|.||||
  Rat   246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC 310

  Fly   426 GTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDE 490
            |||||||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:||::|||.:..|
  Rat   311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE 375

  Fly   491 AKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDK 555
            ||:||:|||.|||.:|||||.:|.|||..|.|||:|.|.|:..||:.|||||||||:|||||||:
  Rat   376 AKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDE 440

  Fly   556 EFTGESVELTPPDPTGPLGSIAEE--PLFPQFSYQGDMASTLGTS 598
            |||.:.:.:||||....:..:..|  |.||||||     |..||:
  Rat   441 EFTAQMITITPPDQDDSMECVDSERRPHFPQFSY-----SASGTA 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Akt1NP_732113.3 PH_PKB 105..214 CDD:269947 61/106 (58%)
PH 107..211 CDD:278594 61/103 (59%)
S_TKc 266..523 CDD:214567 191/257 (74%)
STKc_PKB 270..590 CDD:270723 227/322 (70%)
Akt1NP_150233.1 PH_PKB 4..111 CDD:269947 61/104 (59%)
Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250 14..19 4/4 (100%)
Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250 23..25 1/1 (100%)
STKc_PKB_alpha 124..479 CDD:270746 227/357 (64%)
Inhibitor binding. /evidence=ECO:0000250 228..230 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..480 11/30 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 425 1.000 Domainoid score I591
eggNOG 1 0.900 - - E2759_KOG0690
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 627 1.000 Inparanoid score I817
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D336006at33208
OrthoFinder 1 1.000 - - FOG0001457
OrthoInspector 1 1.000 - - otm45091
orthoMCL 1 0.900 - - OOG6_100157
Panther 1 1.100 - - O PTHR24356
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X913
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.830

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