DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Akt3

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_035915.3	Gene:	Akt3 / 23797	MGIID:	1345147	Length:	479	Species:	Mus musculus

Alignment Length:	487	Identity:	315/487 - (64%)
Similarity:	379/487 - (77%)	Gaps:	25/487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRP 171
            :|||||:.||||:|||||.|||:|.:||..:||:.||.| ...|  :.||||:|..||:|..:||
Mouse     6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQD-VDLP--YPLNNFSVAKCQLMKTERP 67

  Fly   172 KPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAM--TPSEQTDMTDVDM 234
            ||.|||||.|||||||||||.|::..||::|||||:.|:.||....|..|  :|:.|.|
Mouse    68 KPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQID------ 126

  Fly   235 ATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKK 299
             .|.|:|:.         .:::..|:.|:.:|::||:|||||||||||.||||:.|.||:|||||
Mouse   127 -NIGEEEMD---------ASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKK 181

  Fly   300 EVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED 364
            ||||.|||||||||||||||:|.||||.||||||||.|||||||:||||||||:|||.||:|:||
Mouse   182 EVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED 246

  Fly   365 RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPE 429
            |||||||||:|||.||||..|:|||||||||:||||||||:.|||||||.||...|.||||||||
Mouse   247 RTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPE 311

  Fly   430 YLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNL 494
            |||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:|::||||.::.:||:|
Mouse   312 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSL 376

  Fly   495 LAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTG 559
            |:|||.|||.||||||.||.|||..|.||:.:||.|:..||:.|||||||||:|||||||:|||.
Mouse   377 LSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441

  Fly   560 ESVELTPP---DPTGPLGSIAE-EPLFPQFSY 587
            :::.:|||   |..|..|...| .|.||||||
Mouse   442 QTITITPPEKYDDDGMDGMDNERRPHFPQFSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	64/106 (60%)
		PH	107..211	CDD:278594	63/103 (61%)
		S_TKc	266..523	CDD:214567	200/256 (78%)
		STKc_PKB	270..590	CDD:270723	238/322 (74%)
Akt3	NP_035915.3	PH_PKB	4..110	CDD:269947	64/106 (60%)
		STKc_PKB_gamma	132..479	CDD:270745	243/351 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..479		14/29 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I609
eggNOG	1	0.900	-	-		E2759_KOG0690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I842
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm43026
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.850