DRSC/TRiP Functional Genomics Resources

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Protein Alignment Akt1 and Rps6ka2

DIOPT Version :9

Sequence 1:NP_732113.3 Gene:Akt1 / 41957 FlyBaseID:FBgn0010379 Length:611 Species:Drosophila melanogaster
Sequence 2:NP_035429.1 Gene:Rps6ka2 / 20112 MGIID:1342290 Length:733 Species:Mus musculus


Alignment Length:366 Identity:156/366 - (42%)
Similarity:223/366 - (60%) Gaps:15/366 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   234 MATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKAT----AKLYAI 294
            ::.:.|:.:.::..:....  ..|.:|.....||.|||||:|::|||.|.| |.|    .:|||:
Mouse    29 LSRLEEEGIVKEIDISNHV--KEGFEKADPSQFELLKVLGQGSYGKVFLVR-KVTGSDAGQLYAM 90

  Fly   295 KILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHER 359
            |:|||..:..:|.|...: |..:|...||||::.|.|:|||..:|..::.::.||:||..||.|.
Mouse    91 KVLKKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV 154

  Fly   360 IFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTF 424
            :|||:..:||.||:..||.:||..||||||||.||:|||::||||:.||||.||...:.:...:|
Mouse   155 MFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSF 219

  Fly   425 CGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITD 489
            |||.||:||||::...:.|:.|||..||:|:||:.|.|||..:|......|||..::..|:.::.
Mouse   220 CGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSA 284

  Fly   490 EAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFD 554
            ||::||..|..::|..|||.|.|.|:||:.||||.:|:|..|..|:|.|||||.|....||.:||
Mouse   285 EAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKPPFKPAVGRPEDTFHFD 349

  Fly   555 KEFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGDMASTL 595
            .|||..    ||.|..|...|.....||..||:   :||:|
Mouse   350 PEFTAR----TPTDSPGVPPSANAHHLFRGFSF---VASSL 383

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Akt1NP_732113.3 PH_PKB 105..214 CDD:269947
PH 107..211 CDD:278594
S_TKc 266..523 CDD:214567 121/260 (47%)
STKc_PKB 270..590 CDD:270723 147/323 (46%)
Rps6ka2NP_035429.1 S_TKc 59..318 CDD:214567 121/260 (47%)
STKc_RSK_N 63..379 CDD:270734 147/324 (45%)
STKc_RSK3_C 411..703 CDD:271080
Pkinase 415..672 CDD:278497
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R469
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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