DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Rps6ka1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001365809.1	Gene:	Rps6ka1 / 20111	MGIID:	104558	Length:	741	Species:	Mus musculus

Alignment Length:	368	Identity:	155/368 - (42%)
Similarity:	221/368 - (60%)	Gaps:	19/368 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 PSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKA 287
            |..|.|         :::.:.::.|:  |....:|.:|.....||.|||||:|:||||.|.|:..
Mouse    36 PGPQQD---------SDEAILKEISI--THHVKAGSEKADPSQFELLKVLGQGSFGKVFLVRKVT 89

  Fly   288 ---TAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGG 349
               :..|||:|:|||..:..:|.| .|..|..:|...||||::.|.|:|||..:|..::.::.||
Mouse    90 RPDSGHLYAMKVLKKATLKVRDRV-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGG 153

  Fly   350 ELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKED 414
            :||..||.|.:|||:..:||.||:...|.:|||.||||||||.||:|||::||||:.||||.||.
Mouse   154 DLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEA 218

  Fly   415 ITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVE 479
            |.:.:...:||||.||:||||::...:..:.|||..||:|:||:.|.|||..:|.....||||..
Mouse   219 IDHEKKAYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKA 283

  Fly   480 EVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQV 544
            ::..|:.::.||::||..|..::|..|||.|.|..:||:.|.|:::|:|..|..::|.|||||.|
Mouse   284 KLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREIKPPFKPAV 348

  Fly   545 TSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSY 587
            ....||.|||.|||..    ||.|..|...|.....||..||:
Mouse   349 AQPDDTFYFDTEFTSR----TPRDSPGIPPSAGAHQLFRGFSF 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	120/259 (46%)
		STKc_PKB	270..590	CDD:270723	145/321 (45%)
Rps6ka1	NP_001365809.1	STKc_RSK_N	72..388	CDD:270734	145/321 (45%)
Rps6ka1	NP_001365809.1	STKc_RSK1_C	422..712	CDD:271077
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940