Protein Alignment Akt and Prkg2

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_032952.3
• Gene: Prkg2 / 19092
• MGIID: 108173
• Length: 762
• Species: Mus musculus
• Alignment Length: 709
• Identity: 179/709 - (25%)
• Similarity: 302/709 - (42%)
• Gaps: 175/709 - (24%)

  Fly     1 MNYLPFVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSG-SAE----- 59
            :|.|..|:.    |...:|...|..::|.......|.::      |.|......:| |||
Mouse    79 LNKLQDVIH----VQGGSPLQASPDKVPLDVHRKTSGLV------SLHSRRGAKAGVSAEPTTRT 133

  Fly    60 -------KFSWQQSWPSRTSAAPTHDSGTMSINTTFDLSSPSVTS-------GHALTEQTQVVKE 110
                   :||::::...:.|:.....:..::.|.......|....       |....:.:.|:|:
Mouse   134 YDLNKPPEFSFEKARVRKDSSEKKLITDALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYVIKQ 198

  Fly   111 GWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTP--SDF----LLNNFTVRGCQIMTVD 169
            |   :.|.||       ||| ::|||..::.:...| |.|  :.|    :|.|.| |...:..:.
Mouse   199 G---EPGNHI-------FVL-AEGRLEVFQGEKLLS-SIPMWTTFGELAILYNCT-RTASVKAIT 250

  Fly   170 RPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVS----------SRLIDV-------- 216
            ..|  |:.:....:..::.||    ::...:::...:|:||          :::||.
Mouse   251 NVK--TWALDREVFQNIMRRT----AQARDEEYRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDK 309

  Fly   217 -------------------GEVAMTPS------------------------------------EQ 226
                               |:|.:|.|                                    |:
Mouse   310 GDYIIREGEEGSTFFILAKGKVKVTQSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEE 374

  Fly   227 TDMT--DVDMATIAE-----DELSEQFSVQGTTCNSSGVKK--------------VTLE------ 264
            .|:.  .:|..|..:     |||.:.......|.|....|:              ::||
Mouse   375 NDVACLVIDRETFNQTVGTFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKE 439

  Fly   265 ------------NFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRV 317
                        |.|.:..||.|.||:|.|.:.|.....:|:|.::|:.|:...:..|..:|.|:
Mouse   440 KVARFSSTSPFQNLEIIATLGVGGFGRVELVKVKNENVAFAMKCIRKKHIVDTKQQEHVYSEKRI 504

  Fly   318 LKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHER-IFTEDRTRFYGAEIISALGYLH 381
            |:....||::.|..:|:.|..:..:::...|||| |.:..:| .|.|..::|..|.:..|..|||
Mouse   505 LEELCSPFIVKLYRTFKDNKYVYMLLEACLGGEL-WSILRDRGSFDEPTSKFCVACVTEAFDYLH 568

  Fly   382 SQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVD 446
            ..||||||||.|||:||.||::|:.|||..|: |..|:.|.||||||||:||||:.:..:..:||
Mouse   569 RLGIIYRDLKPENLILDADGYLKLVDFGFAKK-IGSGQKTWTFCGTPEYVAPEVILNKGHDFSVD 632

  Fly   447 WWGTGVVMYEMICGRLPFYNRDHDVLFTLIL--VEEVKFPRNITDEAKNLLAGLLAKDPKKRLGG 509
            :|..|:::||::.|..||...|..:.:.|||  :|::.|||.||...::|:..|..::|.:|||.
Mouse   633 FWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDLIRRLCRQNPTERLGN 697

  Fly   510 GKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPD 568
            .|:.:.:|:.|.:....||..|..:.:|.|.:.:::...|..||||....:.|   |||
Mouse   698 LKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKGV---PPD 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	27/124 (22%)
		STKc_PKB	270..590	CDD:270723	112/302 (37%)
Prkg2	NP_032952.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..138		4/19 (21%)
		cGMP-binding, high affinity, cAMP-binding, moderate affinity. /evidence=ECO:0000250|UniProtKB:Q13237	168..283		26/133 (20%)
		CAP_ED	168..273	CDD:237999	26/123 (21%)
		cGMP-binding, high affinity, cAMP-binding, low affinity. /evidence=ECO:0000250|UniProtKB:Q13237	286..416		16/129 (12%)
		CAP_ED	286..401	CDD:237999	13/114 (11%)
		STKc_cGK	459..718	CDD:270724	100/260 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	740..762		8/17 (47%)