Protein Alignment Akt and Prkcb

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_032881.1
• Gene: Prkcb / 18751
• MGIID: 97596
• Length: 673
• Species: Mus musculus
• Alignment Length: 616
• Identity: 213/616 - (34%)
• Similarity: 302/616 - (49%)
• Gaps: 96/616 - (15%)

  Fly     6 FVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPT----SGSAEKFSWQQS 66
            ||:.:|.....:...|| |.:.|.|......:...|      |..||||    .||.......|.
Mouse    72 FVVHKRCHEFVTFSCPG-ADKGPASDDPRSKHKFKI------HTYSSPTFCDHCGSLLYGLIHQG 129

  Fly    67 WPSRTSAAPTHDSGTMSINTTFDLSSPSVTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLH 131
            ....|.....|....|::        ||:..    |:.|:        :||       :.|...|
Mouse   130 MKCDTCMMNVHKRCVMNV--------PSLCG----TDHTE--------RRG-------RIYIQAH 167

  Fly   132 SDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIE-------- 188
            .|..::....:.|.:. .|.|  .|..:....::..:..||.     ...|.|..|:
Mouse   168 IDREVLIVVVRDAKNL-VPMD--PNGLSDPYVKLKLIPDPKS-----ESKQKTKTIKCSLNPEWN 224

  Fly   189 RTFAV---ESELERQ------QWTEAIRN--VSSRLIDVGEV---------AMTPSEQTDMTDVD 233
            .||..   ||:.:|:      .|....||  :.|....:.|:         .:...|:.:..:|.
Mouse   225 ETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFKLLSQEEGEYFNVP 289

  Fly   234 M---ATIAEDELSEQFS----VQGTTC-------------NSSGVKKVTLENFEFLKVLGKGTFG 278
            :   .:...:||.::|.    .|||..             |:....::.|.:|.||.|||||:||
Mouse   290 VPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGKGSFG 354

  Fly   279 KVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNH-PFLISLKYSFQTNDRLCFV 342
            ||:|...|.|.:|||:|||||:|:||.|:|..|:.|.|||..... |||..|...|||.|||.||
Mouse   355 KVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFV 419

  Fly   343 MQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVAD 407
            |:|||||:|.:|:.....|.|....||.|||...|.:|.|:|||||||||:|::||.:||||:||
Mouse   420 MEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIAD 484

  Fly   408 FGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVL 472
            ||:|||:|..|.|||||||||:|:|||::....||::||||..||::|||:.|:.||...|.|.|
Mouse   485 FGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDEL 549

  Fly   473 FTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIP 537
            |..|:...|.:|::::.||..:..||:.|.|.||||.|.:..::|:.|.||..|:|..|..|:|.
Mouse   550 FQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQ 614

  Fly   538 PPFKPQVTSDTDTRYFDKEFTGESVELTPPD 568
            ||:||:... .:...||:.||.....|||||
Mouse   615 PPYKPKACG-RNAENFDRFFTRHPPVLTPPD 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	24/127 (19%)
		STKc_PKB	270..590	CDD:270723	152/300 (51%)
Prkcb	NP_032881.1	C1_cPKC_rpt1	35..92	CDD:410383	6/20 (30%)
		C1_cPKC_rpt2	102..155	CDD:410386	15/70 (21%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	25/144 (17%)
		STKc_cPKC_beta	341..663	CDD:270767	155/305 (51%)