DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and sgk-1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001041299.1	Gene:	sgk-1 / 181697	WormBaseID:	WBGene00004789	Length:	463	Species:	Caenorhabditis elegans

Alignment Length:	469	Identity:	178/469 - (37%)
Similarity:	255/469 - (54%)	Gaps:	76/469 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 CQIMTVDRPKPFTFIIR---G--LQWT-TVIERTFAVESEL----------------------ER 199
            |.::..|..|...:.:|   |  :|.| ...||.|..|.::                      :|
Worm    19 CNVIIGDDKKTVVYALRIGNGPIMQKTFEEYERFFTTEKDMIPATIFTAPKKKFLQADSKFYEKR 83

  Fly   200 QQWTEAIRNVSSRLI-------DVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSG 257
            :.|   |..:|..|:       ||.......|...|..:||:..      ||:
Worm    84 RVW---ILVISQHLVDNNLRSEDVRRFFHLESPDDDENNVDLGP------SER------------ 127

  Fly   258 VKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVL-KST 321
             |..|..:|::|..:|||:||:|...|.|.|.|:||:|||.||.|.:|:||.|.:.|..|| .:.
Worm   128 -KTATANDFDYLTTIGKGSFGRVYQVRHKETKKIYAMKILSKEHIRKKNEVKHVMAERNVLINNF 191

  Fly   322 NHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGII 386
            .||||:||.:|||..::|.||:.::||||||.||..|:.|:|.|:|||.|||..||||||.:.||
Worm   192 KHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYAAEIACALGYLHEKNII 256

  Fly   387 YRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTG 451
            |||||.||||||..|::.:.||||||||:...:||.||||||||||||::....|.:.||||..|
Worm   257 YRDLKPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKPYDKTVDWWCLG 321

  Fly   452 VVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKE 516
            .|:||||.|..|||::||:.::..|:.:.::...||:.....|:.|||.||..||| |.::|.::
Worm   322 SVLYEMIFGLPPFYSKDHNEMYDKIINQPLRLKHNISVPCSELITGLLQKDRSKRL-GHRNDFRD 385

  Fly   517 IQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPL 581
            |:.||||..::|..|:.:::..||.|:|.:..||....|||.  .:::.|       .|:|.:.|
Worm   386 IRDHPFFLPVDWDKLLNRELKAPFIPKVKNAMDTSNISKEFV--EIQIDP-------SSLAPQQL 441

  Fly   582 --------FPQFSY 587
                    |..|::
Worm   442 AVTHRDHDFENFTF 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	15/78 (19%)
		PH	107..211	CDD:278594	14/75 (19%)
		S_TKc	266..523	CDD:214567	133/257 (52%)
		STKc_PKB	270..590	CDD:270723	150/327 (46%)
sgk-1	NP_001041299.1	S_TKc	135..392	CDD:214567	133/257 (52%)
sgk-1	NP_001041299.1	STKc_SGK	139..456	CDD:270727	150/327 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850