DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and akt-2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_510357.3	Gene:	akt-2 / 181524	WormBaseID:	WBGene00000103	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	501	Identity:	261/501 - (52%)
Similarity:	347/501 - (69%)	Gaps:	24/501 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 VTSGHALTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFT 159
            :::.:|..::..:|.|.||.|:||||:|||.|||:|..||.|:|:||||.:....|..  ||||.
Worm     1 MSTENAHLQKEDIVIESWLHKKGEHIRNWRPRYFILFRDGTLLGFRSKPKEDQPLPEP--LNNFM 63

  Fly   160 VRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSS--RLID-VGEVAM 221
            :|....:.:|:|:|..||:|.|||||||||||..:|...||.|.|||:.|||  ||.: .|..:|
Worm    64 IRDAATVCLDKPRPNMFIVRCLQWTTVIERTFYADSADFRQMWIEAIQAVSSHNRLKENAGNTSM 128

  Fly   222 -------TPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKK------VTLENFEFLKVLG 273
                   .||.::|: ::|..:...|.     ..:.|..|....::      ||:::|:||||||
Worm   129 QEEDTNGNPSGESDV-NMDATSTRSDN-----DFESTVMNIDEPEEVPRKNTVTMDDFDFLKVLG 187

  Fly   274 KGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDR 338
            :||||||||||||::.|||||||::||:::.:.||||||||:|||.:..||||..||||||....
Worm   188 QGTFGKVILCREKSSDKLYAIKIIRKEMVVDRSEVAHTLTENRVLYACVHPFLTLLKYSFQAQYH 252

  Fly   339 LCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHI 403
            :||||::.||||||.||...:.|:|.||||||:|||.||||||.:.|:|||:||||||||:||||
Worm   253 ICFVMEFANGGELFTHLQRCKTFSEARTRFYGSEIILALGYLHHRNIVYRDMKLENLLLDRDGHI 317

  Fly   404 KVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRD 468
            |:.|||||||:|.||..|.|||||||||||||::|.||.::|||||.|||||||:||||||..::
Worm   318 KITDFGLCKEEIKYGDKTSTFCGTPEYLAPEVIEDIDYDRSVDWWGVGVVMYEMMCGRLPFSAKE 382

  Fly   469 HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVL 533
            :..||.||...::|||..::.||..||:|||.:.|.||||.|.||.:|:....||..::|...:.
Worm   383 NGKLFELITTCDLKFPNRLSPEAVTLLSGLLERVPAKRLGAGPDDAREVSRAEFFKDVDWEATLR 447

  Fly   534 KKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEE 579
            |::.|||||.|.|:|||.:||:|||...|:||||.....|.::.||
Worm   448 KEVEPPFKPNVMSETDTSFFDREFTSMPVQLTPPRRGEELPTVDEE 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	58/110 (53%)
		PH	107..211	CDD:278594	55/103 (53%)
		S_TKc	266..523	CDD:214567	163/256 (64%)
		STKc_PKB	270..590	CDD:270723	187/310 (60%)
akt-2	NP_510357.3	PH_PKB	11..116	CDD:269947	56/106 (53%)
		PH	13..115	CDD:278594	55/103 (53%)
		S_TKc	180..437	CDD:214567	163/256 (64%)
		PKc_like	184..509	CDD:304357	187/310 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156042
Domainoid	1	1.000	373	1.000	Domainoid score	I468
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	549	1.000	Inparanoid score	I621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm14317
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930