DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and tpa-1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001379590.1	Gene:	tpa-1 / 176825	WormBaseID:	WBGene00006599	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	347	Identity:	158/347 - (45%)
Similarity:	212/347 - (61%)	Gaps:	12/347 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 VKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVL-KST 321
            |||..|.:|..|||||||:||||:|...|...:.||:|.|||:||::.|:...|..|.||| .::
Worm   367 VKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILAS 431

  Fly   322 NHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGII 386
            ..|||..|..|||||:.|.|||:|:|||:|..|:...:.|.|.|||||..||:.||.:||:..||
Worm   432 QCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNNII 496

  Fly   387 YRDLKLENLLLDKDGHIKVADFGLCKEDIT-YGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGT 450
            ||||||:|:|||.|||||:||||:.|.::. ......||||||:|::||::....|.:|||:|..
Worm   497 YRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFWSF 561

  Fly   451 GVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVK 515
            ||:||||:.|:.||:....|.||..||.|...||:.|:.||...|:.|..::|..|||..:....
Worm   562 GVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNPNTRLGMPECPDG 626

  Fly   516 EIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEP 580
            .|:.|.||..::|.....:::||||||.:.|::|...||.:||.|...|||......|.||..|
Worm   627 PIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALTPVHDKNLLASIDPE- 690

  Fly   581 LFPQFSYQGDMASTLGTSSHIS 602
            .|..|||         |:.|.|
Worm   691 AFLNFSY---------TNPHFS 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	124/258 (48%)
		STKc_PKB	270..590	CDD:270723	149/321 (46%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387
		STKc_nPKC_theta_like	379..700	CDD:270744	150/330 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910