DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and rsks-1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_499447.2	Gene:	rsks-1 / 176554	WormBaseID:	WBGene00012929	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	148/379 - (39%)
Similarity:	220/379 - (58%)	Gaps:	30/379 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 GEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVI 281
            |:::..|...:.|         ||.:.|...:..:..|...| :|..|:|:.|||||||.:|||.
Worm    44 GQISAPPPSSSYM---------EDPMMESIQLCASAINPPNV-RVGPEDFQLLKVLGKGGYGKVF 98

  Fly   282 LCREKA---TAKLYAIKILKKEVII--QKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCF 341
            ..|:..   ..:::|:|:|:|..|:  ||| .|||..|..:|::...||:..|.|:|||..:|..
Worm    99 QVRKTTGSDNGQIFAMKVLQKATIVRNQKD-TAHTKAERNILEAVKSPFICDLLYAFQTGGKLYL 162

  Fly   342 VMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVA 406
            :::|::|||||.||..|.:|.|:..:||.:||:.:|.:||.|||||||||.||:|||..||:|:.
Worm   163 ILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEHLHQQGIIYRDLKPENILLDAYGHVKLT 227

  Fly   407 DFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDV 471
            |||||||:|...:.|.|||||.||:|||:|....:|:|||||..|.:|::|:.|..||...:...
Worm   228 DFGLCKEEIEGDQKTHTFCGTIEYMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRK 292

  Fly   472 LFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKI 536
            ....||...:..|..:::||::|:..||.:....|||.|..|.:||::|.||.:.:|..:..:::
Worm   293 TIDKILKGRLTLPAYLSNEARDLIKKLLKRHVDTRLGAGLSDAEEIKSHAFFKTTDWNLVYARQL 357

  Fly   537 PPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGD 590
            ..||||.:.:|.||..||..||    ::||.|          .|....||..||
Worm   358 EAPFKPNIENDEDTSLFDARFT----KMTPVD----------SPCETNFSLNGD 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	116/261 (44%)
		STKc_PKB	270..590	CDD:270723	134/324 (41%)
rsks-1	NP_499447.2	S_TKc	83..344	CDD:214567	116/261 (44%)
rsks-1	NP_499447.2	STKc_p70S6K	86..408	CDD:270736	137/327 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840