DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and M03C11.1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_499294.1	Gene:	M03C11.1 / 176456	WormBaseID:	WBGene00010838	Length:	379	Species:	Caenorhabditis elegans

Alignment Length:	296	Identity:	96/296 - (32%)
Similarity:	156/296 - (52%)	Gaps:	15/296 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 SGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKS 320
            ||.....|::|..::.:|:|.||||.:.:|:.|.|.:|:|.:.|...|:|...|:.:.|..:|..
Worm    18 SGKSAPCLQHFSVIRSIGRGAFGKVCIVQERKTKKYFALKYMNKRRCIEKGVAANVIRELTLLSK 82

  Fly   321 TNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGI 385
            .:|||:::|.|:||..|.:..|...:.||:|.:|||.:..|.|||.:.|..||..|:.|||...|
Worm    83 MSHPFIVNLWYTFQDGDYMYMVSDLLLGGDLRYHLSQQGKFAEDRAKLYLCEICLAVEYLHEMKI 147

  Fly   386 IYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEV------LDDNDYGQA 444
            ::||:|.||:|||:.||..:.|..|..: :...:...::.||..|:|||:      ::|. |...
Worm   148 VHRDIKPENILLDEQGHAHLTDLNLATQ-LEDDQLATSYSGTRPYMAPEIYATYLEIEDG-YDSR 210

  Fly   445 VDWWGTGVVMYEMICGRLPF---YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKR 506
            ||||..||..|||:.||.||   .....:..:.......:.:|.:...:....:..:|..|.:||
Worm   211 VDWWALGVCFYEMLRGRTPFEFSSRTKPEEAYVAFRESSIPYPAHWPTDLIQFINSMLKFDKEKR 275

  Fly   507 LGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKP 542
            |.|    ::.|:.|.:...|::..:..||..|.|.|
Worm   276 LVG----LEAIKKHSYTERIDFKSVFEKKPSPVFIP 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	87/265 (33%)
		STKc_PKB	270..590	CDD:270723	92/282 (33%)
M03C11.1	NP_499294.1	STKc_Yank1	27..287	CDD:270730	87/265 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910