Protein Alignment Akt and wts-1

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_492699.1
• Gene: wts-1 / 172896
• WormBaseID: WBGene00007047
• Length: 908
• Species: Caenorhabditis elegans
• Alignment Length: 679
• Identity: 178/679 - (26%)
• Similarity: 280/679 - (41%)
• Gaps: 167/679 - (24%)

  Fly    15 VASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSG--SAEKFSWQQSWPS-----RTS 72
            |..||        |.:||....|      .....|...|...  |.|..|.::...:     .||
 Worm   249 VVKAP--------PPNPTMLNHN------KNMAPPPPPPAKSTISIETMSEERKADNIQRLYHTS 299

  Fly    73 AAPTHDSGTMSINTTFDLSSPSVTSGHA----LTEQTQVVKEGWLMKRGEHIKNWRQRYFVLHSD 133
            ......|..:|||    ::||..|..:.    |..::.::  |.........||:......|..|
 Worm   300 MDKKTASSVVSIN----VASPHTTKVNVGDSPLPSKSFII--GPRYTADVDRKNFVNYKDELRPD 358

  Fly   134 GRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDR---PKPFTFIIRGLQW-----------T 184
            .||:     |:.|.:...||....|..|..:|....|   |.|        |:           :
 Worm   359 PRLI-----PSTSDANHEDFRPILFKPRNLEITMKSRAQPPPP--------QYNQPSEPPPKRVS 410

  Fly   185 TVIERT---------------------FAVESELER--QQWTEAIRNVSSRLIDVGEVAMTPSEQ 226
            :.|:||                     |.:|..:||  ||:.|..:.:...     |..|..::.
 Worm   411 SPIDRTLLEPYIKNTRRVQPCKPNMLRFYMEQHVERLLQQYKEREKRMKQL-----EKEMVSAQL 470

  Fly   227 TDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKL 291
            .|:....|..:.:.:.|:...::.        :|::..:|..:..:|.|.||||.|.|:..|.|:
 Worm   471 PDIMRNKMLGLLQQKESKYTRLRR--------QKMSKSHFTVISHIGVGAFGKVSLVRKNDTRKV 527

  Fly   292 YAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLS 356
            ||:|.|:|..:|.|.:.||...|..:|...:.|:::.|.:|||.:..|.|:|:||.||::...|.
 Worm   528 YAMKSLEKADVIMKQQAAHVKAERDILAEADSPWIVRLFFSFQDDACLYFIMEYVPGGDMMTLLI 592

  Fly   357 HERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLC------KEDI 415
            .:.||.||..|||.||:..|:.|:|:.|.|:||||.:|:|:|:.||||:.|||||      .:..
 Worm   593 QKGIFEEDLARFYIAELACAIEYVHNVGFIHRDLKPDNILIDQHGHIKLTDFGLCTGLRWTHDRR 657

  Fly   416 TYGR-----------------------------------TTKTFCGTPEYLAPEVLDDNDYGQAV 445
            .||.                                   |..:..||..|:||||:....:.|:.
 Worm   658 YYGPENDHHRVDSFSLPPEVAAIDKSVKVLNVRQQTRRITAHSLVGTGNYMAPEVIAKTGHNQSC 722

  Fly   446 DWWGTGVVMYEMICGRLPFYN-----RDHDVL-------FTLILVEEVKFPRNITDEAKNLLAGL 498
            |||.|||::|||:.||:||::     ..|.:.       ||        :..|::.|...::..|
 Worm   723 DWWSTGVILYEMVFGRVPFHDDTPGGTQHRIKNWRNFLDFT--------YCGNLSKECLMMIQQL 779

  Fly   499 LAKDPKKRLGGGKDDVKE----IQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTG 559
            :. |...|||....||.|    ::.||:|..|:|.:|...:....:.|:||.|.||..|  |...
 Worm   780 IC-DASSRLGSHGKDVAERTAQVKNHPWFRGIDWVNLRKLRADYIYIPRVTHDEDTSNF--ETFQ 841

  Fly   560 ESVELTPPDPTGPLGSIAEEPLFPQFSYQ 588
            ::.....|:..|     ...|.|.:|:|:
 Worm   842 DNDRADKPNVRG-----LHNPAFYEFTYR 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	28/145 (19%)
		STKc_PKB	270..590	CDD:270723	121/376 (32%)
wts-1	NP_492699.1	MobB_LATS	437..497	CDD:439269	12/72 (17%)
		STKc_LATS	500..868	CDD:270749	122/382 (32%)