DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and rskn-1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001122504.1	Gene:	rskn-1 / 172647	WormBaseID:	WBGene00011352	Length:	804	Species:	Caenorhabditis elegans

Alignment Length:	408	Identity:	164/408 - (40%)
Similarity:	235/408 - (57%)	Gaps:	31/408 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 AIRNVSSRLIDVGEVAMTPSEQTDMTDVDMAT---------IAEDELSEQFSVQGTTCNSSGVKK 260
            :|.|||..:....:..|..|.::|.||....|         |.:...:..|.:.....:||...:
Worm    16 SIENVSPGIDQCKDHRMDVSMRSDPTDCSSDTTNTFHSSIHIIQPPPNNGFRLMNWKTDSSSETE 80

  Fly   261 VTL------------ENFEFLKVLGKGTFGKVILCRE---KATAKLYAIKILKKEVIIQKDEVAH 310
            :.:            ..||.|||||:|:||||.|.|:   :.:..:||:|:|||..:..:|. ..
Worm    81 IDIGDVRKCGEKADPRQFELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDR-QR 144

  Fly   311 TLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIIS 375
            |..|..:|...:|||::.|.|:|||..:|..::.::.||:||..||.|.:||||..:||.||:..
Worm   145 TKLERNILAHISHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTL 209

  Fly   376 ALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDND 440
            ||.:|||.||:|||||.||:|||.||||||.||||.||.|...:.|.:||||.||:||||::...
Worm   210 ALEHLHSLGIVYRDLKPENILLDADGHIKVTDFGLSKEAIDSEKKTYSFCGTVEYMAPEVINRRG 274

  Fly   441 YGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKK 505
            :..|.|:|..||:|:||:.|.|||..||.:...|.||..::..|..:|.||::||..|..::.:.
Worm   275 HSMAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAKLSMPHFLTQEAQSLLRALFKRNSQN 339

  Fly   506 RLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPD-P 569
            |||.|.|.|:||:.|.|||.|::..|:.|:|.|||||.:::...|.|||.|||    :.||.| |
Worm   340 RLGAGPDGVEEIKRHAFFAKIDFVKLLNKEIDPPFKPALSTVDSTSYFDPEFT----KRTPKDSP 400

  Fly   570 TGPLGSIAEEPLFPQFSY 587
            ..|..:...| :|..||:
Worm   401 ALPASANGHE-IFRGFSF 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	4/8 (50%)
		PH	107..211	CDD:278594	3/5 (60%)
		S_TKc	266..523	CDD:214567	122/259 (47%)
		STKc_PKB	270..590	CDD:270723	147/322 (46%)
rskn-1	NP_001122504.1	S_TKc	98..357	CDD:214567	122/259 (47%)
		STKc_RSK_N	102..418	CDD:270734	147/322 (46%)
		STKc_RSK_C	447..744	CDD:270993
		S_TKc	448..706	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940