Protein Alignment Akt and Dmpk

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: XP_006539579.1
• Gene: Dmpk / 13400
• MGIID: 94906
• Length: 653
• Species: Mus musculus
• Alignment Length: 488
• Identity: 146/488 - (29%)
• Similarity: 228/488 - (46%)
• Gaps: 102/488 - (20%)

  Fly   206 IRNVSSRLIDVGEVAMTPSEQTDM-----TDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTL-- 263
            :|.:...::|.|.:.:.|  ..|:     .::..:.:|:|:....| :|.....::.:|:|.|
Mouse     7 LRQLQQLVLDPGFLGLEP--LLDLLLGVHQELGASHLAQDKYVADF-LQWVEPIAARLKEVRLQR 68

  Fly   264 ENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLIS 328
            ::||.|||:|:|.|.:|.:.:.|.|.::||:||:.|..::::.||:....|..||...:..::..
Mouse    69 DDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVKGDRRWITQ 133

  Fly   329 LKYSFQTNDRLCFVMQYVNGGELFWHLSH--ERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLK 391
            |.::||..:.|..||:|..||:|...||.  |||..| ..|||.|||:.|:..:|..|.::||:|
Mouse   134 LHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAE-MARFYLAEIVMAIDSVHRLGYVHRDIK 197

  Fly   392 LENLLLDKDGHIKVADFGLCKEDITYGRTTKTFC-GTPEYLAPEVLD-------DNDYGQAVDWW 448
            .:|:|||:.|||::||||.|.:....|....... |||:||:||:|.       ...||...|||
Mouse   198 PDNILLDRCGHIRLADFGSCLKLQPDGMVRSLVAVGTPDYLSPEILQAVGGGPGAGSYGPECDWW 262

  Fly   449 GTGVVMYEMICGRLPFY-------------NRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLA 500
            ..||..|||..|:.|||             .|:|   .:|.|.:.|     :.:||::|:.|||.
Mouse   263 ALGVFAYEMFYGQTPFYADSTAETYAKIVHYREH---LSLPLADTV-----VPEEAQDLIRGLLC 319

  Fly   501 KDPKK-RLG-GGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFD--------- 554
              |.: ||| ||..|   .|.||||..::|..  |:...|||.|.....|||..||
Mouse   320 --PAEIRLGRGGAGD---FQKHPFFFGLDWEG--LRDSVPPFTPDFEGATDTCNFDVVEDRLTAM 377

  Fly   555 --------------------KEFTGESV------ELTPPDPTGPL-------------GSIAEEP 580
                                ..|.|.|.      :...|||| |:             |...:.|
Mouse   378 VSGGGETLSDMQEDMPLGVRLPFVGYSYCCMAFRDNQVPDPT-PMELEALQLPVSDLQGLDLQPP 441

  Fly   581 LFP--QFSYQGDMASTLGTSSHISTSTSLASMQ 611
            :.|  |.:.:.|:.:.....:...|:.:|..:|
Mouse   442 VSPPDQVAEEADLVAVPAPVAEAETTVTLQQLQ 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	1/7 (14%)
		STKc_PKB	270..590	CDD:270723	127/394 (32%)
Dmpk	XP_006539579.1	Protein Kinases, catalytic domain	69..405	CDD:473864	120/351 (34%)
		DMPK_coil	472..532	CDD:117396	1/3 (33%)