DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Rps6ka2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_038934903.1	Gene:	Rps6ka2 / 117269	RGDID:	620676	Length:	762	Species:	Rattus norvegicus

Alignment Length:	392	Identity:	165/392 - (42%)
Similarity:	232/392 - (59%)	Gaps:	23/392 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 EVAMTPSEQTDMTDVDMATIAEDE-------LSEQFSVQGTTCNS---SGVKKVTLENFEFLKVL 272
            ::..||.:.|:....|....||.:       ..|:..|:....:|   .|.:|.....||.||||
  Rat    30 DIEPTPEDTTEEGKGDTTASAETQPASSSSSAEEEGIVKEIDISSHVKEGFEKADPSQFELLKVL 94

  Fly   273 GKGTFGKVILCREKAT----AKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSF 333
            |:|::|||.|.| |.|    .:|||:|:|||..:..:|.|...: |..:|...||||::.|.|:|
  Rat    95 GQGSYGKVFLVR-KVTGSDAGQLYAMKVLKKATLKVRDRVRSKM-ERDILAEVNHPFIVKLHYAF 157

  Fly   334 QTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLD 398
            ||..:|..::.::.||:||..||.|.:|||:..:||.||:..||.:||..||||||||.||:|||
  Rat   158 QTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLD 222

  Fly   399 KDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLP 463
            ::||||:.||||.||.|.:.:...:||||.||:||||::...:.|:.|||..||:|:||:.|.||
  Rat   223 EEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLP 287

  Fly   464 FYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINW 528
            |..:|......|||..::..|:.::.||::||..|..::|..|||.|.|.|:||:.||||.:|:|
  Rat   288 FQGKDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDW 352

  Fly   529 TDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGDMAS 593
            ..|..|:|.|||||.|....||.:||.|||..    ||.|..|...|.....||..||:   :||
  Rat   353 NKLYRKEIKPPFKPAVGRPEDTFHFDPEFTAR----TPTDSPGVPPSANAHHLFRGFSF---VAS 410

  Fly   594 TL 595
            :|
  Rat   411 SL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	122/260 (47%)
		STKc_PKB	270..590	CDD:270723	148/323 (46%)
Rps6ka2	XP_038934903.1	STKc_RSK_N	92..408	CDD:270734	148/324 (46%)
Rps6ka2	XP_038934903.1	STKc_RSK3_C	440..732	CDD:271080
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910