DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and Akt1

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001159366.1	Gene:	Akt1 / 11651	MGIID:	87986	Length:	488	Species:	Mus musculus

Alignment Length:	468	Identity:	290/468 - (61%)
Similarity:	362/468 - (77%)	Gaps:	26/468 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRP 171
            :||||||.||||:||.||.|||:|.:||..:||:.:|.|.....|.  ||||:|..||:|..:||
Mouse     6 IVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESP--LNNFSVAQCQLMKTERP 68

  Fly   172 KPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAM-----TPSEQTDMTD 231
            :|.|||||.|||||||||||.||:..||::|..||:.|:..|....|..|     :||:.:...:
Mouse    69 RPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEE 133

  Fly   232 VDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKI 296
            ::: ::|:.:                 .:||:..||:||:|||||||||||.:||||.:.||:||
Mouse   134 MEV-SLAKPK-----------------HRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI 180

  Fly   297 LKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIF 361
            ||||||:.||||||||||:|||:::.||||.:|||||||:|||||||:|.||||||:|||.||:|
Mouse   181 LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVF 245

  Fly   362 TEDRTRFYGAEIISALGYLHSQ-GIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFC 425
            :|||.|||||||:|||.||||: .::|||||||||:||||||||:.|||||||.|..|.|.||||
Mouse   246 SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFC 310

  Fly   426 GTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDE 490
            |||||||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:||::|||.:..|
Mouse   311 GTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE 375

  Fly   491 AKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDK 555
            ||:||:|||.|||.:|||||.:|.|||..|.|||:|.|.|:..||:.|||||||||:|||||||:
Mouse   376 AKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDE 440

  Fly   556 EFTGESVELTPPD 568
            |||.:.:.:||||
Mouse   441 EFTAQMITITPPD 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	60/106 (57%)
		PH	107..211	CDD:278594	60/103 (58%)
		S_TKc	266..523	CDD:214567	191/257 (74%)
		STKc_PKB	270..590	CDD:270723	219/300 (73%)
Akt1	NP_001159366.1	PH_PKB	4..111	CDD:269947	60/104 (58%)
		PH	6..104	CDD:278594	57/97 (59%)
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	14..19		4/4 (100%)
		Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250	23..25		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..137		4/27 (15%)
		Pkinase	150..408	CDD:278497	185/258 (72%)
		STKc_PKB	154..466	CDD:270723	221/312 (71%)
		Inhibitor binding. /evidence=ECO:0000250	228..230		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I609
eggNOG	1	0.900	-	-		E2759_KOG0690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I842
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm43026
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860