DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and Rps6ka3

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_683747.1	Gene:	Rps6ka3 / 110651	MGIID:	104557	Length:	740	Species:	Mus musculus

Alignment Length:	398	Identity:	162/398 - (40%)
Similarity:	234/398 - (58%)	Gaps:	28/398 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 TPSEQTD----MTDVDMATIAEDEL---SEQFSVQGTTCN---SSGVKKVTLENFEFLKVLGKGT 276
            :||:..:    :.|..|   .|:|:   :|:.|::.....   ..|.:|.....||.|||||:|:
Mouse    17 SPSDSAENGQQIMDEPM---GEEEINPQTEEGSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS 78

  Fly   277 FGKVILCRE---KATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDR 338
            ||||.|.::   ....:|||:|:|||..:..:|.| .|..|..:|...||||::.|.|:|||..:
Mouse    79 FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGK 142

  Fly   339 LCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHI 403
            |..::.::.||:||..||.|.:|||:..:||.||:..||.:|||.||||||||.||:|||::|||
Mouse   143 LYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHI 207

  Fly   404 KVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRD 468
            |:.||||.||.|.:.:...:||||.||:||||::...:.|:.|||..||:|:||:.|.|||..:|
Mouse   208 KLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKD 272

  Fly   469 HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVL 533
            .....|:||..::..|:.::.||::||..|..::|..|||.|.|.|:||:.|.||::|:|..|..
Mouse   273 RKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYR 337

  Fly   534 KKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSY-------QGDM 591
            ::|.|||||......||.|||.|||.:    ||.|..|...|.....||..||:       :...
Mouse   338 REIHPPFKPATGRPEDTFYFDPEFTAK----TPKDSPGIPPSANAHQLFRGFSFVAITSDDESQA 398

  Fly   592 ASTLGTSS 599
            ..|:|..|
Mouse   399 MQTVGVHS 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	121/259 (47%)
		STKc_PKB	270..590	CDD:270723	146/329 (44%)
Rps6ka3	NP_683747.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		6/26 (23%)
		STKc_RSK_N	72..388	CDD:270734	146/320 (46%)
		STKc_RSK2_C	402..740	CDD:271078	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940