Protein Alignment Akt and akt1

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001268730.1
• Gene: akt1 / 101910198
• ZFINID: ZDB-GENE-130730-1
• Length: 474
• Species: Danio rerio
• Alignment Length: 498
• Identity: 307/498 - (61%)
• Similarity: 372/498 - (74%)
• Gaps: 36/498 - (7%)

  Fly   107 VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKP--ADSASTPSDFLLNNFTVRGCQIMTVD 169
            :||||||.||||:||.||.|||:|.|||..:||:.:|  .|...||    ||||:|..||:|..:
Zfish     7 IVKEGWLHKRGEYIKTWRPRYFLLKSDGTFIGYKERPQDVDQLETP----LNNFSVAQCQLMKTE 67

  Fly   170 RPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPS-EQTDMTDVD 233
            ||||.|||||.|||||||||||.||:..|||:||:||:.|:..|....|..|..| |.|||
Zfish    68 RPKPNTFIIRCLQWTTVIERTFHVETPEERQEWTKAIQTVAESLQKQEEEMMDASAEHTDM---- 128

  Fly   234 MATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILK 298
                 |..||:.            ..|||:.:||:||:|||||||||||.:||||.|.||:||||
Zfish   129 -----ETSLSKP------------PHKVTMHDFEYLKLLGKGTFGKVILVKEKATGKYYAMKILK 176

  Fly   299 KEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTE 363
            ||||:.||||||||||:|||:::.||||.:||.||||:|.|||||:|.||||||:|||.||:|:|
Zfish   177 KEVIVAKDEVAHTLTENRVLQNSRHPFLTALKSSFQTHDHLCFVMEYANGGELFFHLSRERVFSE 241

  Fly   364 DRTRFYGAEIISALGYLHSQ-GIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGT 427
            :|..||||||:|||.||||: .::|||||||||:||||||:|:.|||||||.||.|.|.||||||
Zfish   242 ERACFYGAEIVSALHYLHSERNVVYRDLKLENLMLDKDGHVKITDFGLCKEGITDGATMKTFCGT 306

  Fly   428 PEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAK 492
            |||||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:|:::|||.:..:||
Zfish   307 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEDIRFPRTLAPDAK 371

  Fly   493 NLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEF 557
            :||:|||.|||.:|||||.||.|||..|.||..|.|.|:..||:.|||||||||:|||||||:||
Zfish   372 SLLSGLLKKDPMQRLGGGPDDAKEIMQHKFFTGIVWQDVYEKKLVPPFKPQVTSETDTRYFDEEF 436

  Fly   558 TGESVELTPPDPTGPLGSIAEE--PLFPQFSYQGDMASTLGTS 598
            ||:::.:|||.....:.:...|  |.||||||     |..||:
Zfish   437 TGQTITITPPGQDDCMEAFDSERRPHFPQFSY-----SASGTA 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	65/108 (60%)
		STKc_PKB	270..590	CDD:270723	222/322 (69%)
akt1	NP_001268730.1	PH_PKB	5..112	CDD:269947	65/108 (60%)
		Protein Kinases, catalytic domain	120..473	CDD:473864	237/378 (63%)