DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and SGK2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001186193.1	Gene:	SGK2 / 10110	HGNCID:	13900	Length:	367	Species:	Homo sapiens

Alignment Length:	327	Identity:	167/327 - (51%)
Similarity:	217/327 - (66%)	Gaps:	7/327 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 NFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTE-SRVLKSTNHPFLIS 328
            :|:||||:|||.:|||:|.:.|:....||:|:|:|:.|::|.|.:|.:.| |.:||:..||||:.
Human    34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 98

  Fly   329 LKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLE 393
            |:|||||.::|.||:.||||||||:||..||.|.|.|.|||.||:.||:|||||..|||||||.|
Human    99 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPE 163

  Fly   394 NLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMI 458
            |:|||..||:.:.|||||||.:....||.||||||||||||||....|.:|||||..|.|:|||:
Human   164 NILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEML 228

  Fly   459 CGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF 523
            .|..|||::|...::..||.:.::.|...|..|.:||..||.||.::|| |.|.|..||:.|.||
Human   229 HGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFF 292

  Fly   524 ASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELT---PPDPTGPLGSIAEEPLFPQF 585
            :.|||.||..|::.|||.|.||...|.::||.|||.|:|..:   .||...  .|......|..|
Human   293 SPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVA--SSSGASSAFLGF 355

  Fly   586 SY 587
            ||
Human   356 SY 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	138/257 (54%)
		STKc_PKB	270..590	CDD:270723	164/322 (51%)
SGK2	NP_001186193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		STKc_SGK2	39..359	CDD:270754	164/322 (51%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		4/9 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850