Protein Alignment Akt and SGK2

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_057360.3
• Gene: SGK2 / 10110
• HGNCID: 13900
• Length: 367
• Species: Homo sapiens
• Alignment Length: 327
• Identity: 167/327 - (51%)
• Similarity: 217/327 - (66%)
• Gaps: 7/327 - (2%)

  Fly   265 NFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTE-SRVLKSTNHPFLIS 328
            :|:||||:|||.:|||:|.:.|:....||:|:|:|:.|::|.|.:|.:.| |.:||:..||||:.
Human    34 DFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVG 98

  Fly   329 LKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLE 393
            |:|||||.::|.||:.||||||||:||..||.|.|.|.|||.||:.||:|||||..|||||||.|
Human    99 LRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPE 163

  Fly   394 NLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMI 458
            |:|||..||:.:.|||||||.:....||.||||||||||||||....|.:|||||..|.|:|||:
Human   164 NILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEML 228

  Fly   459 CGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF 523
            .|..|||::|...::..||.:.::.|...|..|.:||..||.||.::|| |.|.|..||:.|.||
Human   229 HGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRL-GSKADFLEIKNHVFF 292

  Fly   524 ASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELT---PPDPTGPLGSIAEEPLFPQF 585
            :.|||.||..|::.|||.|.||...|.::||.|||.|:|..:   .||...  .|......|..|
Human   293 SPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVA--SSSGASSAFLGF 355

  Fly   586 SY 587
            ||
Human   356 SY 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947
		STKc_PKB	270..590	CDD:270723	164/322 (51%)
SGK2	NP_057360.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		STKc_SGK2	39..359	CDD:270754	164/322 (51%)
		Nuclear localization signal. /evidence=ECO:0000250	68..78		4/9 (44%)