DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and rps6ka3

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_031752603.1	Gene:	rps6ka3 / 100496161	XenbaseID:	XB-GENE-480947	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	362	Identity:	159/362 - (43%)
Similarity:	221/362 - (61%)	Gaps:	11/362 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 MTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKA---TAK 290
            |.|.|.....|..::|   :..|.....|.:|.....||.|||||:|:||||.|.|:.:   ..:
Frog    31 MCDEDNENNDEGNINE---IAITHHVKEGHEKADPSQFELLKVLGQGSFGKVFLVRKISGTDAGQ 92

  Fly   291 LYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHL 355
            |||:|:|||..:..:|.| .|..|..:|...||||::.|.|:|||..:|..::.::.||:||..|
Frog    93 LYAMKVLKKATLKVRDRV-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRL 156

  Fly   356 SHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRT 420
            |.|.:|||:..::|.||:..||.:|||.||||||||.||:|||::||||:.||||.||.|.:.:.
Frog   157 SKEVMFTEEDVKYYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKK 221

  Fly   421 TKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPR 485
            ..:||||.||:||||::...:.|:.|||..||:|:||:.|.|||..:|.....|:||..::..|:
Frog   222 AYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQ 286

  Fly   486 NITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDT 550
            .:|.||::||..|..::|..|||.|.|.|:||:.|||||:|:|..|..::..|||||......||
Frog   287 FLTPEAQSLLRMLFKRNPTNRLGAGPDGVEEIKRHPFFATIDWNKLYRRENQPPFKPATGGPEDT 351

  Fly   551 RYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSY 587
            .|||.|||.:    ||.|..|...|.....||..||:
Frog   352 FYFDPEFTAK----TPKDSPGIPASANAHQLFRGFSF 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	123/259 (47%)
		STKc_PKB	270..590	CDD:270723	148/321 (46%)
rps6ka3	XP_031752603.1	STKc_RSK_N	69..385	CDD:270734	148/321 (46%)
rps6ka3	XP_031752603.1	STKc_RSK2_C	399..737	CDD:271078
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910