DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and sgk3

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_012820716.1	Gene:	sgk3 / 100491891	XenbaseID:	XB-GENE-492582	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	183/381 - (48%)
Similarity:	234/381 - (61%)	Gaps:	29/381 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 TPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVKKVTL----------ENFEFLKVLGKGT 276
            :|..|:|.::      .|||..:|       .|.|..:.|.|          .:||:||::|||:
Frog   115 SPKHQSDPSE------DEDERVDQ-------KNGSASRDVNLGPSGNPHAKPSDFEYLKLIGKGS 166

  Fly   277 FGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRV-LKSTNHPFLISLKYSFQTNDRLC 340
            ||||:|.|.|...:.||:|:|:|.||:.|.|..|.:.|..| ||:..||||::|.|||||:|:|.
Frog   167 FGKVVLTRGKRDGRYYAVKVLQKNVILNKKEQRHIMAERNVLLKNVKHPFLVTLHYSFQTSDKLF 231

  Fly   341 FVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKV 405
            ||:.::||||||:||..||.|.|.|..||.|||.||||||||..|||||||.||:|||..|||.:
Frog   232 FVLDFINGGELFFHLQRERYFAEPRALFYAAEIGSALGYLHSIDIIYRDLKPENILLDSQGHIVL 296

  Fly   406 ADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHD 470
            .|||||||.|:...||.|||||||||||||:....|...||||..|.|:|||:.|..||||||..
Frog   297 TDFGLCKEGISNSDTTLTFCGTPEYLAPEVIVKQPYDNTVDWWCLGSVLYEMLHGLPPFYNRDTA 361

  Fly   471 VLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKK 535
            .::..||.:.:....:|:..|.::|..||.||||.|| |..:|.::|:.|.|||||||.|||.||
Frog   362 TMYENILHKPLTTRPDISLPAISILEELLEKDPKLRL-GVNNDFQDIKNHAFFASINWADLVEKK 425

  Fly   536 IPPPFKPQVTSDTDTRYFDKEFTGESVELT---PPDPTGPLGSIAE-EPLFPQFSY 587
            :.||:.|.|....|...||||||.|.|..:   ..|.:....|:.| :..|..|||
Frog   426 MTPPYDPHVNGPDDISNFDKEFTEEMVPYSVCVSSDYSIVNASVEEADDAFVGFSY 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	140/257 (54%)
		STKc_PKB	270..590	CDD:270723	169/323 (52%)
sgk3	XP_012820716.1	PX_domain	7..114	CDD:383026
sgk3	XP_012820716.1	STKc_SGK3	159..484	CDD:270755	170/324 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920