DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and prkcdb

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001352166.1	Gene:	prkcdb / 100150844	ZFINID:	ZDB-GENE-111129-1	Length:	685	Species:	Danio rerio

Alignment Length:	329	Identity:	155/329 - (47%)
Similarity:	213/329 - (64%)	Gaps:	7/329 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 KVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNH 323
            :|:|.:|.|.||||||:||||:|...|...:.:|||.|||:|::..|:|..|:.|.|||. :..:
Zfish   352 RVSLNDFVFQKVLGKGSFGKVMLAELKGKGQYFAIKALKKDVVLMDDDVECTMVEKRVLALAWEN 416

  Fly   324 PFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYR 388
            |||..|..:||:.:.|.|||:|:|||:|.:|:..:..|...|..||.||||..|.||||:||:||
Zfish   417 PFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLYRATFYAAEIICGLQYLHSKGIVYR 481

  Fly   389 DLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVV 453
            ||||:|::||||||||:||||:|||::.......||||||:|:|||:|....|..:||||..||:
Zfish   482 DLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEILLGQKYSFSVDWWSFGVL 546

  Fly   454 MYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQ 518
            :|||:.|:.||...|.|.||..|.::...:||.||.|||:||..|..:||.:|||    .|..|:
Zfish   547 LYEMLIGQSPFQGDDEDELFDSIRMDVPHYPRWITKEAKDLLEKLFERDPTRRLG----VVGNIR 607

  Fly   519 AHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFP 583
            .|.||.:|||..|..:::.|||||:|.|.:|...||:||..|...|:..|..  |....::..|.
Zfish   608 GHAFFKTINWPALEKREVSPPFKPKVKSSSDCSNFDREFLSEKPRLSQSDKN--LIDSMDQTAFA 670

  Fly   584 QFSY 587
            .||:
Zfish   671 GFSF 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	128/257 (50%)
		STKc_PKB	270..590	CDD:270723	151/319 (47%)
prkcdb	NP_001352166.1	C1_1	160..209	CDD:278556
		C1_1	232..284	CDD:278556
		PKc_like	362..677	CDD:328722	151/319 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910