DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and akt3b

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_001923454.3	Gene:	akt3b / 100149794	ZFINID:	ZDB-GENE-110309-3	Length:	479	Species:	Danio rerio

Alignment Length:	487	Identity:	306/487 - (62%)
Similarity:	374/487 - (76%)	Gaps:	25/487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRP 171
            ||||||:.||||:|||||.|||:|.:||..:||:.||.|:...   :.||||:|..||:|..:||
Zfish     6 VVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDADLA---YPLNNFSVAKCQLMKTERP 67

  Fly   172 KPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGE--VAMTPSEQTDMTDVDM 234
            ||.|||||.|||||||||||.|::..||.:|.|||:.|:.:|....|  :..:|..|.:
Zfish    68 KPNTFIIRCLQWTTVIERTFHVDTPEERDEWVEAIQMVADKLAKQEEEGILCSPISQIE------ 126

  Fly   235 ATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKK 299
             .:.|:|:.         .::|..|:.|:.:|::||:|||||||||||.||||:...||:|||||
Zfish   127 -NVNEEEMD---------TSTSHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGTYYAMKILKK 181

  Fly   300 EVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED 364
            ||||.|||||||||||||||:|.||||.||||||||.|||||||:||||||||:|||.||:|:||
Zfish   182 EVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED 246

  Fly   365 RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPE 429
            |||||||||:|||.||||..|:|||||||||:||||||||:.|||||||.||...|.||||||||
Zfish   247 RTRFYGAEIVSALDYLHSAKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPE 311

  Fly   430 YLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNL 494
            |||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:||:||||.::.:||:|
Zfish   312 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIKFPRTLSADAKSL 376

  Fly   495 LAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTG 559
            |:|||.|||.||||||.||.|||..|.||.:::|.|:..||:.|||.|||:|:|||||||:|||.
Zfish   377 LSGLLIKDPNKRLGGGPDDAKEIMRHSFFTALDWQDVYDKKLVPPFMPQVSSETDTRYFDEEFTA 441

  Fly   560 ESVELTPPDPTGPLGSIAEE----PLFPQFSY 587
            :::.:|||:.....|..|.:    |.||||||
Zfish   442 QTITITPPEKYDEDGMDAADSERRPHFPQFSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	62/106 (58%)
		PH	107..211	CDD:278594	62/103 (60%)
		S_TKc	266..523	CDD:214567	200/256 (78%)
		STKc_PKB	270..590	CDD:270723	233/322 (72%)
akt3b	XP_001923454.3	PH_PKB	4..109	CDD:269947	62/105 (59%)
		PH	6..105	CDD:278594	61/101 (60%)
		PKc_like	132..479	CDD:304357	239/351 (68%)
		S_TKc	148..405	CDD:214567	200/256 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I589
eggNOG	1	0.900	-	-		E2759_KOG0690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	623	1.000	Inparanoid score	I846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm24506
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.830