Protein Alignment Akt and akt2

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001116936.1
• Gene: akt2 / 100144709
• XenbaseID: XB-GENE-484168
• Length: 485
• Species: Xenopus tropicalis
• Alignment Length: 492
• Identity: 303/492 - (61%)
• Similarity: 384/492 - (78%)
• Gaps: 15/492 - (3%)

  Fly   104 QTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKP--ADSASTPSDFLLNNFTVRGCQIM 166
            :..|:|||||.||||:||.||.|||:|.|||..:||:.||  .:.:|.|.   ||||:|..||:|
 Frog     3 EVMVIKEGWLQKRGEYIKTWRPRYFLLKSDGSFIGYKEKPESTEHSSIPP---LNNFSVAECQLM 64

  Fly   167 TVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTD 231
            ..:||:|.||:||.|||||||||||.|::..||::|..||:.|::.|  ..:||  ..|:.:..:
 Frog    65 KTERPRPNTFVIRCLQWTTVIERTFHVDTPEEREEWIIAIQTVANGL--KNQVA--EDEEEEAME 125

  Fly   232 VDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKI 296
            |...:.::...:||..|    ..|.|..|||:.:|::||:|||||||||||.|||::.:.||:||
 Frog   126 VKYGSPSDVSSAEQMDV----AMSKGRPKVTMNDFDYLKLLGKGTFGKVILVREKSSGRYYAMKI 186

  Fly   297 LKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIF 361
            |:|||||.||||||||||||||::|.||||.:|||:|||:|||||||:|.||||||:|||.||:|
 Frog   187 LRKEVIIAKDEVAHTLTESRVLQNTKHPFLTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVF 251

  Fly   362 TEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCG 426
            ||||.|||||||:|||.||||:.::|||:|||||:||||||:|:.|||||||.||.|.|.:||||
 Frog   252 TEDRARFYGAEIVSALEYLHSRNVVYRDIKLENLMLDKDGHVKITDFGLCKEGITDGATMRTFCG 316

  Fly   427 TPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEA 491
            ||||||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:||::|||.::.||
 Frog   317 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEA 381

  Fly   492 KNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKE 556
            |:||||||.||||:|||||.:|.:|:.:|.|||||||.|:..:|:.|||||||||:.||||||.|
 Frog   382 KSLLAGLLKKDPKQRLGGGPNDAQEVMSHRFFASINWQDVTERKLTPPFKPQVTSEIDTRYFDDE 446

  Fly   557 FTGESVELTPPDPTGPLGSIA--EEPLFPQFSYQGDM 591
            ||.:|:.|||||....|.::.  :.|.||||||...:
 Frog   447 FTAQSITLTPPDRYDNLDALESDQRPHFPQFSYSASI 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	60/110 (55%)
		STKc_PKB	270..590	CDD:270723	228/321 (71%)
akt2	NP_001116936.1	PH_PKB	4..112	CDD:269947	61/112 (54%)
		STKc_PKB_beta	160..482	CDD:173686	228/321 (71%)