DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and akt2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001116936.1	Gene:	akt2 / 100144709	XenbaseID:	XB-GENE-484168	Length:	485	Species:	Xenopus tropicalis

Alignment Length:	492	Identity:	303/492 - (61%)
Similarity:	384/492 - (78%)	Gaps:	15/492 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 QTQVVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKP--ADSASTPSDFLLNNFTVRGCQIM 166
            :..|:|||||.||||:||.||.|||:|.|||..:||:.||  .:.:|.|.   ||||:|..||:|
Frog     3 EVMVIKEGWLQKRGEYIKTWRPRYFLLKSDGSFIGYKEKPESTEHSSIPP---LNNFSVAECQLM 64

  Fly   167 TVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAMTPSEQTDMTD 231
            ..:||:|.||:||.|||||||||||.|::..||::|..||:.|::.|  ..:||  ..|:.:..:
Frog    65 KTERPRPNTFVIRCLQWTTVIERTFHVDTPEEREEWIIAIQTVANGL--KNQVA--EDEEEEAME 125

  Fly   232 VDMATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKI 296
            |...:.::...:||..|    ..|.|..|||:.:|::||:|||||||||||.|||::.:.||:||
Frog   126 VKYGSPSDVSSAEQMDV----AMSKGRPKVTMNDFDYLKLLGKGTFGKVILVREKSSGRYYAMKI 186

  Fly   297 LKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIF 361
            |:|||||.||||||||||||||::|.||||.:|||:|||:|||||||:|.||||||:|||.||:|
Frog   187 LRKEVIIAKDEVAHTLTESRVLQNTKHPFLTALKYAFQTSDRLCFVMEYANGGELFFHLSRERVF 251

  Fly   362 TEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCG 426
            ||||.|||||||:|||.||||:.::|||:|||||:||||||:|:.|||||||.||.|.|.:||||
Frog   252 TEDRARFYGAEIVSALEYLHSRNVVYRDIKLENLMLDKDGHVKITDFGLCKEGITDGATMRTFCG 316

  Fly   427 TPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEA 491
            ||||||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:||::|||.::.||
Frog   317 TPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEA 381

  Fly   492 KNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKE 556
            |:||||||.||||:|||||.:|.:|:.:|.|||||||.|:..:|:.|||||||||:.||||||.|
Frog   382 KSLLAGLLKKDPKQRLGGGPNDAQEVMSHRFFASINWQDVTERKLTPPFKPQVTSEIDTRYFDDE 446

  Fly   557 FTGESVELTPPDPTGPLGSIA--EEPLFPQFSYQGDM 591
            ||.:|:.|||||....|.::.  :.|.||||||...:
Frog   447 FTAQSITLTPPDRYDNLDALESDQRPHFPQFSYSASI 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	60/110 (55%)
		PH	107..211	CDD:278594	60/105 (57%)
		S_TKc	266..523	CDD:214567	189/256 (74%)
		STKc_PKB	270..590	CDD:270723	228/321 (71%)
akt2	NP_001116936.1	PH_PKB	4..112	CDD:269947	61/112 (54%)
akt2	NP_001116936.1	STKc_PKB_beta	160..482	CDD:173686	228/321 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	417	1.000	Domainoid score	I648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48773
Inparanoid	1	1.050	609	1.000	Inparanoid score	I909
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm48149
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190