DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and prkcha

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001116528.1	Gene:	prkcha / 100144561	ZFINID:	ZDB-GENE-080402-5	Length:	712	Species:	Danio rerio

Alignment Length:	480	Identity:	194/480 - (40%)
Similarity:	274/480 - (57%)	Gaps:	45/480 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 KPADSASTPSDFLLN---NFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELE---RQ 200
            |||...||...|.:|   .|::...::.|      |......|.|..|.:.......::.   |.
Zfish   224 KPAKEQSTTQGFSINVPHKFSIHNYKVPT------FCDHCGSLLWGIVRQGLHCKICKMNVHIRC 282

  Fly   201 QWTEA----IRNV--SSRLIDVGEVAMTPSEQTDMTDVDMATIAEDELSEQFSVQGTTCNSSGVK 259
            :...|    |.||  :::|.::|   :.|...|....|.:|.:  |..|...||:|....|...:
Zfish   283 KGNVAPNCGINNVELANKLAEMG---LQPGGLTKRNSVGLAGL--DAQSRTLSVRGERGQSKKEQ 342

  Fly   260 --KVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-ST 321
              |:.:.||..|:|||||:||||:|.|...:.:::|:|||||::|:|.|:|..|:||.|||. ::
Zfish   343 CLKLGISNFTLLQVLGKGSFGKVMLVRLNGSDQVFAVKILKKDIILQDDDVECTMTEKRVLSLAS 407

  Fly   322 NHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGII 386
            .||:|..|...|||.:||.|||::||||:|.:|:...|.|.|:|.|||.|||.|||.:|||:||:
Zfish   408 THPYLTQLYCCFQTPERLFFVMEFVNGGDLMFHIQKSRKFEENRARFYTAEITSALIFLHSKGIV 472

  Fly   387 YRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTG 451
            ||||||:|:|||||||.|:||||:|||.:..|..|.||||||:|:|||:|.:..||.:||||..|
Zfish   473 YRDLKLDNVLLDKDGHCKLADFGMCKEGMFDGIVTGTFCGTPDYIAPEILQELLYGPSVDWWALG 537

  Fly   452 VVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLG-----GGK 511
            |::|||:.|..||...:.|.||..||.||:.:...::..|.::|.|.|.|:|.:|||     ||:
Zfish   538 VLLYEMLSGHAPFEAENEDDLFESILTEEIIYASWLSTNAVDILKGFLTKNPSRRLGCVATEGGE 602

  Fly   512 DDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSI 576
               ..:..||||..|:|..|..:.:.|||||::.:..|...||.:||.|...|||.|
Zfish   603 ---TAVTGHPFFTDIDWDKLDQRALEPPFKPRIKTAEDVNNFDPDFTQEDPTLTPID-------- 656

  Fly   577 AEEPLFPQFSYQGDMASTLGTSSHI 601
              |.:.|..| |.|......|||.:
Zfish   657 --ESILPSIS-QDDFRGFSFTSSEL 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	18/83 (22%)
		PH	107..211	CDD:278594	18/80 (23%)
		S_TKc	266..523	CDD:214567	134/262 (51%)
		STKc_PKB	270..590	CDD:270723	156/325 (48%)
prkcha	NP_001116528.1	C2_PKC_epsilon	3..136	CDD:175981
		C1_1	169..220	CDD:278556
		C1_1	241..293	CDD:278556	8/57 (14%)
		S_TKc	351..611	CDD:214567	134/262 (51%)
		PKc_like	355..678	CDD:304357	160/336 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910