Protein Alignment Akt and prkcb

DIOPT Version :10

• Sequence 1: NP_732113.3
• Gene: Akt / 41957
• FlyBaseID: FBgn0010379
• Length: 611
• Species: Drosophila melanogaster
• Sequence 2: NP_001103513.1
• Gene: prkcb / 100038043
• XenbaseID: XB-GENE-486491
• Length: 670
• Species: Xenopus tropicalis
• Alignment Length: 620
• Identity: 215/620 - (34%)
• Similarity: 302/620 - (48%)
• Gaps: 104/620 - (16%)

  Fly     6 FVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPT----SGSAEKFSWQQS 66
            ||:.:|.....:...|| |.:.|.|......:...|      |..||||    .||.......|.
 Frog    69 FVVHKRCHEFVTFSCPG-ADKGPASDDPRSKHKFKI------HTYSSPTFCDHCGSLLYGLIHQG 126

  Fly    67 WPSRTSAAPTHDSGTMSINTTFDLSSPSVTSGHALTEQTQVVKEGWLMKRGE-HIK-NWRQRYF- 128
            ....|.....|....|::        ||:..    |:.|:        :||. ||| ..|:...
 Frog   127 MKCETCMMNVHKRCVMNV--------PSLCG----TDHTE--------RRGRIHIKAEIREEVLT 171

  Fly   129 VLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIE----- 188
            |...|.|.:    .|.|.......::         ::..:..||.     ...|.|..|:
 Frog   172 VTVGDARNL----VPMDPNGLSDPYV---------KLKLIPDPKS-----ESKQKTKTIKCSLNP 218

  Fly   189 ---RTFAV---ESELERQ------QWTEAIRN---------VSSRL---IDVGEVAMTPSEQTDM 229
               .:|..   ||:.:|:      .|....||         :|..|   :| |...:...|:.:.
 Frog   219 TWNESFKFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELLKAGVD-GWFKLLSQEEGEY 282

  Fly   230 TDVDMATIAE---DELSEQFS----VQGTTC-------------NSSGVKKVTLENFEFLKVLGK 274
            .:|.:....|   :||.::|.    ..||..             |:....::.:.:|.|||||||
 Frog   283 FNVPVPPEGEEGNEELRQKFERAKIGPGTKAVEEKVVNPMPKVDNNETRDRMKVSDFNFLKVLGK 347

  Fly   275 GTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSFQTNDR 338
            |:||||||...|.|.:|||||||||:|:||.|:|..|:.|.|||. |...|||..|...|||.||
 Frog   348 GSFGKVILAERKGTDELYAIKILKKDVVIQDDDVECTMVEKRVLALSGKPPFLTQLHSCFQTMDR 412

  Fly   339 LCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHI 403
            |.|||:|||||:|.:.:.....|.|....||.|||...|.:|||:||:||||||:|::||.:|||
 Frog   413 LYFVMEYVNGGDLMYQIQQVGRFKEPHAVFYAAEIAIGLLFLHSKGIVYRDLKLDNVMLDSEGHI 477

  Fly   404 KVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRD 468
            |:||||:|||::..|.|||||||||:|:|||::....|.::||||..|:::|||:.|:.||...|
 Frog   478 KIADFGMCKENMWDGVTTKTFCGTPDYIAPEIIAYQPYAKSVDWWAFGILLYEMLAGQAPFEGED 542

  Fly   469 HDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVL 533
            .|.||..|:...|.:|::::.||..:..||:.|.|.||||.|.:..::|:.|.||..|:|..|..
 Frog   543 EDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKDHAFFRYIDWEKLER 607

  Fly   534 KKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPD 568
            .:|.||:||:... .:...|||.||.....|||||
 Frog   608 NEIQPPYKPKACG-RNAENFDKFFTRHPPVLTPPD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Akt	NP_732113.3	PH_PKB	105..214	CDD:269947	26/140 (19%)
		STKc_PKB	270..590	CDD:270723	152/300 (51%)
prkcb	NP_001103513.1	C1_cPKC_rpt1	32..89	CDD:410383	6/20 (30%)
		C1_cPKC_rpt2	99..152	CDD:410386	15/70 (21%)
		C2_PKC_alpha_gamma	156..286	CDD:175992	28/148 (19%)
		STKc_cPKC_beta	338..660	CDD:270767	155/305 (51%)