DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and sgk2

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	XP_002932914.2	Gene:	sgk2 / 100036607	XenbaseID:	XB-GENE-982512	Length:	351	Species:	Xenopus tropicalis

Alignment Length:	333	Identity:	170/333 - (51%)
Similarity:	214/333 - (64%)	Gaps:	12/333 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 NFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRV-LKSTNHPFLIS 328
            :|:||||:|||:||||:|.:.|.....||:|:|:|:.|::|.|..|.:.|..| ||:..||||:.
Frog    19 DFDFLKVIGKGSFGKVLLAKRKCDNNFYAVKVLQKKTILKKKEQNHIMAERNVLLKNLKHPFLVG 83

  Fly   329 LKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLE 393
            |.|||||.::|.||:.||||||||.||..||.|.|.|.|||.||:..||||||||.|||||||.|
Frog    84 LHYSFQTAEKLYFVLDYVNGGELFLHLQRERCFLEPRARFYAAEVACALGYLHSQNIIYRDLKPE 148

  Fly   394 NLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMI 458
            |:|||..||:.:.|||||||.:....||.||||||||||||||....|.:.||||..|.|:|||:
Frog   149 NILLDSQGHVVLTDFGLCKEGMEPEETTSTFCGTPEYLAPEVLRKQPYDRTVDWWCLGAVLYEML 213

  Fly   459 CGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF 523
            .|..|||:||...::..||.:.::.|...|....::|.|||.||.:.|| |.|.|.:||:.|.||
Frog   214 YGLPPFYSRDVSQMYDNILSQPLQLPGCKTTATCDILRGLLHKDQRCRL-GAKADFQEIKNHVFF 277

  Fly   524 ASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTG-----PLGSIAEEPLFP 583
            :.|||.||..|:|.||:.|.|....|.|:||.|||.|:|    |...|     .:.|.:....|.
Frog   278 SPINWDDLYHKRIAPPYNPNVAGPGDLRHFDPEFTQEAV----PSSVGRTPDLNVSSCSSSSAFL 338

  Fly   584 QFSY-QGD 590
            .||| |.|
Frog   339 GFSYAQSD 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947
		PH	107..211	CDD:278594
		S_TKc	266..523	CDD:214567	139/257 (54%)
		STKc_PKB	270..590	CDD:270723	166/326 (51%)
sgk2	XP_002932914.2	STKc_SGK2	24..344	CDD:270754	165/324 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.040