DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Akt1 and prkcba

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_957323.1	Gene:	prkcba / 100006675	ZFINID:	ZDB-GENE-040426-1354	Length:	668	Species:	Danio rerio

Alignment Length:	678	Identity:	217/678 - (32%)
Similarity:	315/678 - (46%)	Gaps:	151/678 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FVLQRRSTVVASAPAPGSASRIPESPTTTGSNIINIIYSQSTHPNSSPTSGSAEKFSWQQSWPSR 70
            ||:.:|.........|||                          :..|.|....|:   .|:...
Zfish    68 FVVHKRCHEFVHFSCPGS--------------------------DKGPASDDPRKY---HSFKVH 103

  Fly    71 TSAAPTH------------DSGTMSINTTFDLSS------PSVTSGHALTEQTQVVKEGWLMKRG 117
            |..:||.            ..|...:|...::..      ||:..    |:.|:        |||
Zfish   104 TYTSPTFCDHCGSLLYGLIHQGMRCLNCLMNIHKRCFKHVPSLCG----TDHTE--------KRG 156

  Fly   118 EHIKNWRQRYFVLHSDGRLMGYRSK------PADSA--STP-----------SDFLLNNFTVRGC 163
                   :.:|.....|.::....|      |.|.:  |.|           |:......|::||
Zfish   157 -------RLHFSASITGNVLSVSVKEARNLVPMDPSGLSDPYVKLKLIPDPKSESKQKTKTIKGC 214

  Fly   164 --QIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRN--VSSRLIDVGEVAMTPS 224
              .:...|    |||.::    .|..:|...||.    ..|....||  :.|....:.|: |..|
Zfish   215 LNPVWNED----FTFALK----DTDKDRRLYVEV----WDWDRGTRNDYMGSMSFGISEL-MNQS 266

  Fly   225 ----------EQTDMTDVDMATIAED---ELSEQF---SVQGTTCNSSGVKK------------- 260
                      |:....:|.:....|:   |||::|   .:...|.|:.|..|
Zfish   267 VDGWFKILACEEGVFFNVPVYVDEEEGNKELSKRFERAKIGPGTNNTDGASKNDLSKYDANGNQD 331

  Fly   261 -VTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNH 323
             :.|.:|.|:.|||||:||||:|...|.:.:|||:|||||:|:||.|:|..|:.|.|||. |...
Zfish   332 RMKLADFNFIMVLGKGSFGKVMLAERKGSDELYAVKILKKDVVIQDDDVECTMVEKRVLALSGKP 396

  Fly   324 PFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYR 388
            |||..|...|||.|||.|||:|::||:|.:.:.....|.|....||..||...|.:|||:|||||
Zfish   397 PFLTHLHSCFQTMDRLYFVMEYISGGDLMFQIQQTGKFKEPLAVFYAGEIAIGLFFLHSKGIIYR 461

  Fly   389 DLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVV 453
            ||||:|::||.:||||:||||:|||::....|||||||||:|:|||::....||::||||..||:
Zfish   462 DLKLDNVMLDSEGHIKIADFGMCKENMFDKDTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVL 526

  Fly   454 MYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQ 518
            :|||:.|:.||...|.|.||..|:...|.:|::::.||..:..||:.|.|.||||.|.:..::|:
Zfish   527 LYEMLAGQPPFDGEDEDELFQSIMEHHVSYPKSMSKEAVAICKGLMTKHPGKRLGCGLEGERDIK 591

  Fly   519 AHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFP 583
            .|.||..::|..|..|::.||:||: :...|...||..||.....||||| ...:.::.:|. |.
Zfish   592 EHAFFRFVDWERLQNKEVQPPYKPK-SCGRDAGNFDLFFTRHPPILTPPD-LEVIQNLDQEE-FR 653

  Fly   584 QFSYQGDMASTLGTSSHISTSTSLASMQ 611
            .|||               .:|..|||:
Zfish   654 GFSY---------------VNTKFASMK 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	27/131 (21%)
		PH	107..211	CDD:278594	25/126 (20%)
		S_TKc	266..523	CDD:214567	129/257 (50%)
		STKc_PKB	270..590	CDD:270723	151/320 (47%)
prkcba	NP_957323.1	C1_1	33..85	CDD:278556	4/16 (25%)
		C1_1	98..148	CDD:278556	8/49 (16%)
		C2_PKC_alpha_gamma	155..285	CDD:175992	29/149 (19%)
		PKc_like	337..659	CDD:304357	153/339 (45%)
		S_TKc	338..596	CDD:214567	129/257 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D614710at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920