DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Akt1 and AKT3

DIOPT Version :9

Sequence 1:	NP_732113.3	Gene:	Akt1 / 41957	FlyBaseID:	FBgn0010379	Length:	611	Species:	Drosophila melanogaster
Sequence 2:	NP_001357003.1	Gene:	AKT3 / 10000	HGNCID:	393	Length:	479	Species:	Homo sapiens

Alignment Length:	487	Identity:	312/487 - (64%)
Similarity:	377/487 - (77%)	Gaps:	25/487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRP 171
            :|||||:.||||:|||||.|||:|.:||..:||:.||.| ...|  :.||||:|..||:|..:||
Human     6 IVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQD-VDLP--YPLNNFSVAKCQLMKTERP 67

  Fly   172 KPFTFIIRGLQWTTVIERTFAVESELERQQWTEAIRNVSSRLIDVGEVAM--TPSEQTDMTDVDM 234
            ||.|||||.|||||||||||.|::..||::|||||:.|:.||....|..|  :|:.|.|
Human    68 KPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSPTSQID------ 126

  Fly   235 ATIAEDELSEQFSVQGTTCNSSGVKKVTLENFEFLKVLGKGTFGKVILCREKATAKLYAIKILKK 299
             .|.|:|:.         .:::..|:.|:.:|::||:|||||||||||.||||:.|.||:|||||
Human   127 -NIGEEEMD---------ASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKK 181

  Fly   300 EVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED 364
            ||||.|||||||||||||||:|.||||.||||||||.|||||||:||||||||:|||.||:|:||
Human   182 EVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSED 246

  Fly   365 RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPE 429
            |||||||||:|||.||||..|:|||||||||:||||||||:.|||||||.||...|.||||||||
Human   247 RTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPE 311

  Fly   430 YLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNL 494
            |||||||:|||||:||||||.|||||||:||||||||:||:.||.|||:|::||||.::.:||:|
Human   312 YLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSL 376

  Fly   495 LAGLLAKDPKKRLGGGKDDVKEIQAHPFFASINWTDLVLKKIPPPFKPQVTSDTDTRYFDKEFTG 559
            |:|||.|||.||||||.||.|||..|.||:.:||.|:..||:.|||||||||:|||||||:|||.
Human   377 LSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTA 441

  Fly   560 ESVELTPPDPTGPLG----SIAEEPLFPQFSY 587
            :::.:|||:.....|    .....|.||||||
Human   442 QTITITPPEKYDEDGMDCMDNERRPHFPQFSY 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Akt1	NP_732113.3	PH_PKB	105..214	CDD:269947	64/106 (60%)
		PH	107..211	CDD:278594	63/103 (61%)
		S_TKc	266..523	CDD:214567	200/256 (78%)
		STKc_PKB	270..590	CDD:270723	235/322 (73%)
AKT3	NP_001357003.1	PH_PKB	4..110	CDD:269947	64/106 (60%)
		STKc_PKB_gamma	132..479	CDD:270745	240/351 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..479		7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	426	1.000	Domainoid score	I607
eggNOG	1	0.900	-	-		E2759_KOG0690
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	630	1.000	Inparanoid score	I852
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D336006at33208
OrthoFinder	1	1.000	-	-		FOG0001457
OrthoInspector	1	1.000	-	-		otm40956
orthoMCL	1	0.900	-	-		OOG6_100157
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R469
SonicParanoid	1	1.000	-	-		X913
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.900