DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and CYTIP

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_004279.3	Gene:	CYTIP / 9595	HGNCID:	9506	Length:	359	Species:	Homo sapiens

Alignment Length:	417	Identity:	80/417 - (19%)
Similarity:	142/417 - (34%)	Gaps:	156/417 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 ADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKS 345
            ||.......||::|...||:       :|...|:....|....||..:       :||.:.|..|
Human    16 ADFCAGPAYSSYSTLTGSLT-------MDDNRRIQMLADTVATLPRGR-------KQLALTRSSS 66

  Fly   346 PRQDFGFSLRKAICLDRTESLT-----------------SPIFRPVIFAEPGAGGGATGLLPGDR 393
             ..||.:|.||.:.:::.::.|                 |.:|..:...:..:.....||..||.
Human    67 -LSDFSWSQRKLVTVEKQDNETFGFEIQSYRPQNQNACSSEMFTLICKIQEDSPAHCAGLQAGDV 130

  Fly   394 LIKVNGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNC 458
            |..:||........:.::::||:||..:|:|.                            .||..
Human   131 LANINGVSTEGFTYKQVVDLIRSSGNLLTIET----------------------------LNGTM 167

  Fly   459 NTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQP-ERVWLVHRGGFTAAIRLP 522
             .|:|:                            :|||.:....|. ::.|:.:|     :::|
Human   168 -ILKRT----------------------------ELEAKLQVLKQTLKQKWVEYR-----SLQL- 197

  Fly   523 TASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYAS 587
                   :|:    ||||.           :..|.|:|:.::       |:|.|:...|
Human   198 -------QEH----RLLHG-----------DAANCPSLENMD-------LDELSLFGPL------ 227

  Fly   588 NLIHTKAGPTLLVVNPMAPLSLYSEKVVSM-------FRGCKTEDMPPHVYSLAQTAYRSLVETR 645
                ...||.|:..|.::..|.....:.||       ::.|.:||.....:| .||       :.
Human   228 ----PGPGPALVDRNRLSSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFS-RQT-------ST 280

  Fly   646 RDQSLI------FMGRSGSGKSTSFKH 666
            .|:..|      |:.||.|.::.|..:
Human   281 DDECFIPKEGDDFLRRSSSRRNRSISN 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	23/103 (22%)
		MYSc	556..1317	CDD:214580	27/124 (22%)
		MYSc_Myo18	575..1305	CDD:276837	22/105 (21%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
CYTIP	NP_004279.3	PDZ_signaling	76..161	CDD:238492	16/84 (19%)
CYTIP	NP_004279.3	Interaction with CYTH1	166..188		6/50 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900