DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and SLC9A3R1

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_004243.1	Gene:	SLC9A3R1 / 9368	HGNCID:	11075	Length:	358	Species:	Homo sapiens

Alignment Length:	177	Identity:	42/177 - (23%)
Similarity:	67/177 - (37%)	Gaps:	42/177 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 PPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKV 397
            |.||...:  :|.| ..:||.|         ......:.:.:...|||:.....|||.||||::|
Human    10 PLPRLCCL--EKGP-NGYGFHL---------HGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEV 62

  Fly   398 NGTPVGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLR 462
            ||..|.:...:.::..||.:..||               |.:.....|.|:            |:
Human    63 NGENVEKETHQQVVSRIRAALNAV---------------RLLVVDPETDEQ------------LQ 100

  Fly   463 RSASKRFKRQSRHENGNGGGEEGGA---KGVGHDLEADVADASQPER 506
            :...:..:...|.:...|..|...|   :|.|::.|...||.|.||:
Human   101 KLGVQVREELLRAQEAPGQAEPPAAAEVQGAGNENEPREADKSHPEQ 147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	23/86 (27%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
SLC9A3R1	NP_004243.1	PDZ_signaling	12..91	CDD:238492	26/105 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..192		11/34 (32%)
		PDZ_signaling	152..231	CDD:238492
		EBP50_C	235..358	CDD:312529
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900