DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and DLG5

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	1015	Identity:	205/1015 - (20%)
Similarity:	356/1015 - (35%)	Gaps:	305/1015 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1342 QRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNV---------HRTEEQLKTANEELLM 1397
            |||  ||..:|.|...:|...|.         .|..||..         .:.:|:...|..|||:
Human     4 QRR--ELLAQCQQSLAQAMTEVE---------AVLGLLEAAGALSPGERRQLDEEAGGAKAELLL 57

  Fly  1398 -------------LRAKLEKIECDRSEVKAEN------QKLE------AKLSELTVDLAEERSTA 1437
                         |||.|||.:.....:...|      |..|      :.||.:..|.....|.:
Human    58 KLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAGSTYSVLSTMPSDSESSSSLS 122

  Fly  1438 HIATE------------------------RLEAETAERLKLEKELGDQTN-------KVKNLQET 1471
            .:.|.                        :|...|.||.:|.|.|...|:       ....|...
Human   123 SVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRERNELRKRLAFATHGTAFDKRPYHRLNPD 187

  Fly  1472 TEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLV 1536
            .|:|:::.:.|.|||..:........:          :.|.||:|.:|    .||.|...|....
Human   188 YERLKIQCVRAMSDLQSLQNQHTNALK----------RCEEVAKETDF----YHTLHSRLLSDQT 238

  Fly  1537 ALKKHLEMKLSDAYEEVVEQRQVVGQ-W---KRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRK 1597
            .||..::| |.....:::.:|.::.| |   ||..::...|:.|||...::....|...|...:.
Human   239 RLKDDVDM-LRRENGQLLRERNLLQQSWEDMKRLHEEDQKEIGDLRAQQQQVLKHNGSSEILNKL 302

  Fly  1598 FDAECQSLQ------DAVRQERQAK-----------ERYGREKDVL--QAEKFTLEQTLADTRLD 1643
            :|.....|:      ||:|:....|           |:.|.|...|  |.|..|.::   ||.:.
Human   303 YDTAMDKLEVVKKDYDALRKRYSEKVAIHNADLSRLEQLGEENQRLLKQTEMLTQQR---DTAIQ 364

  Fly  1644 LE----FKEEKLASLQRELEEMTFGGG--------TEEEFAQLRRSKNETERRAKEQEEELDEMA 1696
            |:    ....:..::..||.:.|....        .:.|..:||.::.:|.:.:::..||.|.:.
Human   365 LQHQCALSLRRFEAIHHELNKATAQNKDLQWEMELLQSELTELRTTQVKTAKESEKYREERDAVY 429

  Fly  1697 GQIQLL---------EQAKLRLEMTL-ETMRKEARRESQQRDEELEEVR----------GNGYKK 1741
            .:.:|:         |..||:.|:.| |:..|.:..|.:..:||:|.:|          |...|:
Human   430 SEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKE 494

  Fly  1742 IKALECQLETEHEERTLLLREKHELE-RRLSSMEDRDRV--DRDAEEALNQKLRR---------- 1793
            ::.|..|.:...:|....|:|....: ||..:.::||::  :||:...|...|||
Human   495 VEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELA 559

  Fly  1794 -------DLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELT 1851
                   |.||.|   .|...:|:.||         .|:.:|||.....|
Human   560 EALRSLDDTRKQK---NDVSRELKELK---------EQMESQLEKEARFR--------------- 597

  Fly  1852 EVQAMFDESHRARNDAEERANAAHRDRAELQAQIEENEEELGEL-MKKYSATVKQLNTE------ 1909
              |.|...||.:..|.         |..|.:.::.|.|.|..:: :|.....:.:...|
Human   598 --QLMAHSSHDSAIDT---------DSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGD 651

  Fly  1910 ----------------QINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKR 1958
                            ::.|::...::|:::....:.|:.:..|.:        |:.::.|:.:|
Human   652 CGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLN--------GEGAINMVVRR 708

  Fly  1959 LELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMR 2023
                      |..|.......|.:.::..|::...|:|.|..:.:  :......|:...::.|..
Human   709 ----------RKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAV--LPGSPAAKEGSLAVGDRI 761

  Fly  2024 EEFHAV-----SSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGE--- 2080
            ...:.:     |..|.|||.|                :.::.|.|:|.::  ..|:....|:
Human   762 VAINGIALDNKSLNECESLLR----------------SCQDSLTLSLLKV--FPQSSSWSGQNIF 808

  Fly  2081 EELSESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRI 2145
            |.:.:||:.||......:::     .|.||:..|..|            ||:|.:|..|....|.
Human   809 ENIKDSDKMLSFRAHGPEVQ-----AHNKRNLIQHNN------------STQTDIFYTDRLEDRK 856

  Fly  2146 TVTSP--SSPHIHKLALAAKAIPANK----PDTKPAASTR 2179
            ....|  ||..:|      |..|...    |...|:||.|
Human   857 EPGPPGGSSSFLH------KPFPGGPLQVCPQACPSASER 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769	56/264 (21%)
		COG1340	1565..1833	CDD:224259	75/338 (22%)
		coiled coil	1723..1734	CDD:293879	4/10 (40%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142		6/43 (14%)
		Takusan	130..212	CDD:282652	15/81 (19%)
		TPR_MLP1_2	231..353	CDD:285204	27/122 (22%)
		COG1340	295..587	CDD:224259	66/306 (22%)
		FliJ	310..449	CDD:304890	27/141 (19%)
		BAR	417..601	CDD:299863	47/212 (22%)
		PDZ_signaling	620..707	CDD:238492	11/94 (12%)
		DegQ	<702..771	CDD:223343	11/80 (14%)
		PDZ_signaling	722..790	CDD:238492	13/85 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306
		PDZ	1347..1429	CDD:214570
		dbPDZ_assoc	1427..1499	CDD:293216
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900