Protein Alignment Mhcl and MYH13

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_003793.2
• Gene: MYH13 / 8735
• HGNCID: 7571
• Length: 1938
• Species: Homo sapiens
• Alignment Length: 2008
• Identity: 471/2008 - (23%)
• Similarity: 835/2008 - (41%)
• Gaps: 496/2008 - (24%)

  Fly   530 EENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKA 594
            |.:|:.::.| :...||::.|.|...|.|..|.:||:..:.:|:|.:||:.|::|||:.:|:|.:
Human    56 ENDKVIVKTL-DDRMLTLNNDQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYS 119

  Fly   595 GPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSG 659
            |...:.|||...|.:|..:||:.:||.|.::.|||::|::..||:.::..|.:||::..|.||:|
Human   120 GLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAG 184

  Fly   660 KSTSFKHALNYLALAA-----------GAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQ 713
            |:.:.|..:.|.|..|           |.....:..:.:.| ..:||||||.||..|.|::|..:
Human   185 KTVNTKRVIQYFATIAVTGDKKKETQPGKMQGTLEDQIIQA-NPLLEAFGNAKTVRNDNSSRFGK 248

  Fly   714 LLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENI----T 774
            .:.:.|..||::|||.::..|.|:.|...:|..|.|:||..::::      .|:..|.::    |
Human   249 FIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIMS------NKKPELIDLLLIST 307

  Fly   775 SEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTK 835
            :....||:|..:    .::|    :.:.:.|..|.:.|...::...||:.:..|:.|.|     .
Human   308 NPFDFPFVSQGEVTVASIDD----SEELLATDNAIDILGFSSEEKVGIYKLTGAVMHYG-----N 363

  Fly   836 LGTGSTARTQFANP---TAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSP-----TSD 892
            :......|.:.|.|   ..|.||..|:|:|..::..   ||..|....|....:|..     |:.
Human   364 MKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLK---GLCCPRVKVGNEYVTKGQNVQQVTNS 425

  Fly   893 TGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQV 953
            .|         ||...:|.:....:|..||:|:.|.......|.::|..||:    |
Human   426 VG---------ALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFN-------- 473

  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIE-----MDLASECHPGPLISLIDKAP 1013
              :|..|..|:..|:||..|:|...|..::.|.:|.:|.|     ||||: |     |.||:|.
Human   474 --SLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAA-C-----IELIEKP- 529

  Fly  1014 QNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ- 1076
                             .|:..:|:||.::|.:.|.:|..:|: .|.|...:....:...|..:
Human   530 -----------------MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEA 577

  Fly  1077 -FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRL---YIGSLTRGSGAMVF 1137
             |.|.|..||  |.|.:.||:..::: |.....|.|.|.||.:.::.|   |.|:.|..||....
Human   578 HFSLVHYAGT--VDYNIAGWLDKNKD-PLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKK 639

  Fly  1138 CGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNA 1202
            .|...|    .|.:.||::.|.                 .::.::..||.|..|||.|.:
Human   640 GGKKKG----SSFQTVSAVFRE-----------------NLNKLMTNLRSTHPHFVRCLI----- 678

  Fly  1203 GKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFG 1267
            ...||     :|.           :::..|:..|||.:.|||..|:.|.|||..:...:|.:|:.
Human   679 PNETK-----TPG-----------VMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYR 727

  Fly  1268 LL------AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQ 1326
            :|      .|....:|:.| |::|...::|...:|.|.:::.|::|:|..||..||..|...:..
Human   728 ILNASAIPEGQFIDSKNAS-EKLLNSIDVDREQFRFGNTKVFFKAGLLGLLEEMRDEKLVTLMTS 791

  Fly  1327 LQAFCRGYLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQL 1388
            .||.|||||.|   |||.:||.   ::.|||.|:::|:.|:.|||..|..::.|||.....|:::
Human   792 TQAVCRGYLMRVEFKKMMERRD---SIFCIQYNIRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEM 853

  Fly  1389 KTANEELLMLRAKLEKIECDRSE------------------VKAENQK----------------- 1418
            .|..|:....:.:|.:.|..|.|                  |::|.:.
Human   854 ATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIL 918

  Fly  1419 LEAKLSELTVDLAEER--STAHIATERLEAETAERL------------KLEKELGDQTNKVKNLQ 1469
            ||||:.|||..|.||.  ::..:|.:|...:....|            |:|||.....||||||.
Human   919 LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLS 983

  Fly  1470 ETTEKLEMELICAKSDLNGISED-----EDAENEDGVGGGVYKL--KYERVARELEFT---KRRL 1524
            |....||..:.....:...:.|.     :|.:.|:....|:.|:  |.|:...:||.:   :::|
Human   984 EEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKL 1048

  Fly  1525 HTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNN 1589
            ..    |||:   .|:.||..|..:.|.:::......|.:.|.:|...|::.|:..::::...:.
Human  1049 RA----DLER---AKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSL 1106

  Fly  1590 LLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAE----KFTLEQTLADTRLDLEFKEEK 1650
            ..:||.::..|..:.|::.:..|...:.:..:::..|..|    ...||:....|...:|..:::
Human  1107 QFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKR 1171

  Fly  1651 LASLQ---RELEEMTFG----------------GGTEEEFAQLRRSKNETERRAKEQEEELDEMA 1696
            .|..|   |:|||.|..                ....|:...|:|.|.:.|:...|.:.|:|:||
Human  1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMA 1236

  Fly  1697 GQIQLLEQAKLRLEMTLETMR----------------------KEARRESQ-----QRDEELEEV 1734
            ..|:.|.::|..:|.|..|:.                      ::||.::|     .|.||.|.:
Human  1237 SNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESL 1301

  Fly  1735 RGNGYKKIKALECQLE---TEHEERTL-----------------LLRE--------KHELERRLS 1771
            .....|..:||..|||   .:.||.|.                 ||||        |.||:|.||
Human  1302 ISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALS 1366

  Fly  1772 SME----------DRDRVDRDAE-------------------EALNQK----------------- 1790
            ...          :.|.:.|..|                   |..|.|
Human  1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVED 1431

  Fly  1791 LRRDLRK---------------------YKALLKDAQTQLERLKADTPG---------------- 1818
            |.|||.:                     :|..|.::|.:||..:.::..
Human  1432 LMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496

  Fly  1819 ---KTLIRQLRNQLED--------AESARSL--AMKARQTAEAELTEVQAMFDE----------- 1859
               :||.|:.:|..|:        ||:.::|  |.|.::..|.|.:::|...:|
Human  1497 DQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESK 1561

  Fly  1860 --------------------------------SHRARN------DAEERA-NAAHRDRAELQAQI 1885
                                            |.||..      |||.|: |.|.|.:.:::..:
Human  1562 ILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626

  Fly  1886 EENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHR----LDNVE- 1945
            .|.|.:||...::.:.|.|.|.|.|..:.:::..|::......:||||:|.::.|    |:.:|
Human  1627 NEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEE 1691

  Fly  1946 ------------NLGDPSMAMMSKRLEL----RTKELESRLELE---QATRARLEVQVNRHKEAL 1991
                        .|.:..:...|.|::|    .|..:.::.:||   ...:|.:|..:...:.|.
Human  1692 MKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAE 1756

  Fly  1992 EKLQNEVTQSKM------REMQAQDVIKKSQKSL-RDMREEFHAVSSREQESLTRRKDLEKKVEQ 2049
            ||.:..:|.:.|      :|......:::.:|:| :.:::..|.:...||.:|   |..:|::::
Human  1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAL---KGGKKQIQK 1818

  Fly  2050 MESEGAALKNDLRLALQRIADLQQA---MEEEGEEELSESDESLSSVGSISDLEDRLRPVHVKRS 2111
            :|:....|:|:|.:..:|.|:..:.   .|.:.:|...:::|...::..:.||.|:|: ..||..
Human  1819 LENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQ-AKVKSY 1882

  Fly  2112 SQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTSPSSPHIHKLALAAKAIPANK 2169
            .:|:....  ....:.:|..|.|..|.::.:.|..:   :...::||...::.:.:.|
Human  1883 KRQAEEAE--EQANTQLSRCRRVQHELEEAAERADI---AESQVNKLRAKSRDVGSQK 1935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	437/1841 (24%)
		MYSc_Myo18	575..1305	CDD:276837	201/777 (26%)
MYH13	NP_003793.2	Myosin_N	33..77	CDD:460670	6/21 (29%)
		MYSc_Myh13	100..770	CDD:276887	201/777 (26%)
		Actin-binding. /evidence=ECO:0000250	659..681		7/26 (27%)
		Actin-binding. /evidence=ECO:0000250	761..775		4/13 (31%)
		Myosin_tail_1	850..1927	CDD:460256	221/1092 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1917..1938		3/19 (16%)