Protein Alignment Mhcl and MYO1

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1787
• Identity: 442/1787 - (24%)
• Similarity: 778/1787 - (43%)
• Gaps: 395/1787 - (22%)

  Fly   503 QPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDIC 567
            |.|::.:||          |..|:  :..|.:.:|:           .||...|....|.||::.
Yeast    40 QEEQIGIVH----------PLDST--EVSNLVQVRI-----------SDVFPVNPSTFDKVENMS 81

  Fly   568 ELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMF-----RGCKT---- 623
            ||.:|||.|||:.|.:||..:||:|.:|..|:.:||...|:||||..::::     |..|:
Yeast    82 ELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNRLSKSRLDE 146

  Fly   624 ---EDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLA-LAAGAYNNFINA 684
               |.:|||::::|:.||.:|:...:|||::..|.||:||:.:.|..|.||| :.:|:.:|....
Yeast   147 NSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSGSPSNIAPV 211

  Fly   685 E----------KVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQR 739
            .          |:.....|||:|||.:|..|:|::|..:.:.::|::.|.|..|.::..|.|:.|
Yeast   212 SGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIEWYLLEKSR 276

  Fly   740 AGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAAND---FMRT 801
            ...:...|.::||..:||:|......|.|.|::...:|   :..||...:|.....||   |...
Yeast   277 IVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKD---YKILSNSNQDIIPGINDVENFKEL 338

  Fly   802 VQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDL 866
            :.|...:......:|.|:.::|.|.   :.|..:..:....:..|.|..:|..::  |||:.:|.
Yeast   339 LSALNIIGFSKDQIRWIFQVVAIIL---LIGNIEFVSDRAEQASFKNDVSAICSN--LGVDEKDF 398

  Fly   867 SSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWE---------CLEALVIGLYSEALAAVVALIN 922
            .:|..                .|.|..|.||..:         .|.||...||......:|.:||
Yeast   399 QTAIL----------------RPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMIN 447

  Fly   923 RQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRD 983
            :.:...|.|:..|.|:|..||:    |          :...|..||..|:||..|::...|..:.
Yeast   448 KNLDHGSATLNYIGLLDIAGFEIFENN----------SFEQLCINYTNEKLQQFFNNHMFVLEQS 502

  Fly   984 RYAQELVEIE-MDLASECHPGPLISLID-KAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNS 1046
            .|.:|.::.: :|...:..  ..|.||: |.|..                |:|.||||||:.|.|
Yeast   503 EYLKENIQWDYIDYGKDLQ--LTIDLIESKGPPT----------------GVLPLLDEEAVLPKS 549

  Fly  1047 NDDTFLERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSL 1111
            .|::|..:|.|.:.  ::.|..::......|:|.|..|  .|.|.|:||:..::: |...|.:||
Yeast   550 TDESFYSKLISTWD--QNSSKFKRSRLKNGFILKHYAG--DVEYTVEGWLSKNKD-PLNDNLLSL 609

  Fly  1112 LQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRR--SFTTAGVKRNSIMLQV 1174
            |..|..:.|::|:.....:.|.        ||:|...|.:.|....|  :|.|...:.....:.
Yeast   610 LSSSQNDIISKLFQPEGEKSSS--------AGVEANISNQEVKKSARTSTFKTTSSRHREQQIT- 665

  Fly  1175 KFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRG 1239
                  :::.|..|..|||.| ::.:|..|...:                    |..|:..|||.
Yeast   666 ------LLNQLASTHPHFVRC-IIPNNVKKVKTF--------------------NRRLILDQLRC 703

  Fly  1240 SQVLEAARLHRLGFPESVPLLEFVRRFGLL----------AGDLASNKDVSVEQILAVNELDVAS 1294
            :.|||..||.|.|:|..:...||.:|:.:|          :..|.::...:.|.:|...:||...
Yeast   704 NGVLEGIRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKV 768

  Fly  1295 YRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARK-------KMSQRRVQELAVRC 1352
            |:||.:::.|::|||::||.::||.|::.:|:|.|..|||..||       |:.:.||.....|.
Yeast   769 YKIGNTKLFFKAGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRL 833

  Fly  1353 IQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQ 1417
            ..|.||      :.||:.|.:|:.|||.......:.|..||::..|:..|:::|..:..::.:||
Yeast   834 YNRLVK------EDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQ 892

  Fly  1418 KLEAKLSELTVDLAEER-----------STAHIATERLEAE-----------TAERLKLEKELGD 1460
            |...:| |.|.||..:.           :....::|.|:.:           :.|:|::.:.|.:
Yeast   893 KTVNEL-ENTQDLLNQEKENLRKNESLLNRVKTSSETLQKQFDDLVSEKDEISREKLEVAQNLEE 956

  Fly  1461 QTNKVKNLQE-------TTEKLEM---ELICAKSDLN-GISEDEDAEN---EDGVGGGVYKLKYE 1511
            ...|::.|||       |.|||..   |||...|||| .||:::.:::   |.       |||.|
Yeast   957 AHQKIQGLQETIREREATLEKLHSKNNELIKQISDLNCDISKEQSSQSLIKES-------KLKLE 1014

  Fly  1512 RVARELE------------FTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWK 1564
            ...:.|:            |..:...::.:.|: :||.|:|:..:.:|
Yeast  1015 NEIKRLKDVINSKEEEIKSFNDKLSSSEEDLDI-KLVTLEKNCNIAMS----------------- 1061

  Fly  1565 RKAQKMTNEMNDLRMLLE----EQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDV 1625
             :.|.:..|.:|||...|    |:.|.||.|:.|    ::|...:::.:...::....:.:::|.
Yeast  1062 -RLQSLVTENSDLRSKNENFKKEKAALNNQLKNK----ESELLKMKEKIDNHKKELATFSKQRDD 1121

  Fly  1626 LQAEKFTLEQTLADTRLDL-EFK------EEKLASLQRELEEMTFGGGTEEEFAQLRRSKNET-- 1681
            ..:|...:...|.:||:.| |:|      :|:.::.|||         |:|:..:.|.|..|:
Yeast  1122 AVSEHGKITAELKETRIQLTEYKSNYQKIKEEYSNFQRE---------TKEQEQKKRNSLVESLN 1177

  Fly  1682 ERRAKEQEEELDEMAGQIQLLEQAKLRLE-MTLETMRKEARRESQQRDEELEEVRGNGYKKIKAL 1745
            :.:.||.|..|.:   :|.|.:....|:. .::||.....||.:...|:.|:  :.:..||...|
Yeast  1178 DSKIKELEARLSQ---EISLNQYLNKRISGNSVETNISSTRRSTSYSDDPLD--KEDIIKKYYDL 1237

  Fly  1746 EC-------QLETEHEERTLLLREKHELERRL--SSMEDRDRVDRDAEEALNQKLRRDLRKYKAL 1801
            :.       .||.|.||:..|:......|.||  ||.||             ||::..::|.|.|
Yeast  1238 QLAFTEITRNLENEIEEKKNLISRLRFTETRLASSSFED-------------QKIKAQMKKLKKL 1289

  Fly  1802 LKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARND 1866
            ::|....:       |..:::.:..:...|.||..:..|       .|:..::...|...||..|
Yeast  1290 IQDMDPSI-------PLDSILNEPLDNCPDKESDINKLM-------LEVDYLKRQLDIETRAHYD 1340

  Fly  1867 AEERANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEME-AERNNL 1930
            ||...:|.|....::|.:...:..::.:|  |:.|:.::       |...|.||..|. .:|.||
Yeast  1341 AENAISALHSKFRKIQGESSLSSSDIYKL--KFEASEER-------VKSLEDKLKTMPLRDRTNL 1396

  Fly  1931 --------KEQVAELQ-----HRLDNV---ENLGDPSMAMMSKRLELRTKELESRLELEQATRAR 1979
                    ::.:::.:     ::|:|.   |.|.:.:..:....|:||..:.:..|..||..|.:
Yeast  1397 PVGDIIKNRDSISKYEEEIRYYKLENYKLQEILNESNGKLSQLTLDLRQSKSKEALLSEQLDRLQ 1461

  Fly  1980 LEVQ-VNRHKEALE---KLQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQ------ 2034
            .::: ..|.||.|.   |.|.:..::.|.::|..:        || :||..||:...|:
Yeast  1462 KDLESTERQKELLSSTIKQQKQQFENCMDDLQGNE--------LR-LREHIHALKQAEEDVKNMA 1517

  Fly  2035 ---ESL-TRRKDLEKKVEQMESEGAALKNDLRLALQ-------RIADLQQAMEEEGEEELSESDE 2088
               |.| |:.|..||.:.:.|.|    :||..:.||       |:.|:::.:    .::|:...|
Yeast  1518 SIIEKLKTQNKQKEKLIWEREME----RNDSDMQLQETLLELKRVQDVKKIL----SDDLAHLKE 1574

  Fly  2089 SLSSVGSISDLEDRLRPVHVKRSSQQSLNGSI 2120
            .||:|...|...|.:..:      ::.||.|:
Yeast  1575 RLSAVEDRSQYTDEINRL------KEELNCSL 1600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	403/1629 (25%)
		MYSc_Myo18	575..1305	CDD:276837	202/782 (26%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	442/1787 (25%)
		Smc	1607..>1901	CDD:440809