DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and MYO18B

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_011528760.1 Gene:MYO18B / 84700 HGNCID:18150 Length:2610 Species:Homo sapiens


Alignment Length:2384 Identity:680/2384 - (28%)
Similarity:1106/2384 - (46%) Gaps:435/2384 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 KEAKGTSGG------------PGMGGVTG--VTGSMSTDELLRLDEVRRSLKIRGRRKE------ 69
            |.:.||..|            ||...:.|  ..||.|.|.       .:...|.|.:.:      
Human   120 KSSSGTRSGSQQISQDDQSSSPGSSDILGKESEGSRSPDP-------EQMTSINGEKAQELGSSA 177

  Fly    70 ---KEKLP--SGITADYSADFFAALNADANGGSNGGAVGAADPEQ----------------DRGN 113
               |:.:|  .|:.........|.|:.|           :|.||:                |.|.
Human   178 TPTKKTVPFKRGVRRGDVLLMVAKLDPD-----------SAKPEKTHPHDAPPCKTSPPATDTGK 231

  Fly   114 EEIVASVMTHIESRASN------------------GAG-VSVNYSEVTHSLLSGGL---KNRFLP 156
            |:...:..|...|:||.                  |.| |::...|...|::..||   |...|.
Human   232 EKKGETSRTPCGSQASTEILAPKAEKTRTGGLGDPGQGTVALKKGEEGQSIVGKGLGTPKTTELK 296

  Fly   157 PIPPKPPKRGILKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESL-----YEG----- 211
            ...|:...|   :|:|.......|.:. .|.|...|..|    .||.:..::     .||     
Human   297 EAEPQGKDR---QGTRPQAQGPGEGVR-PGKAEKEGAEP----TNTVEKGNVSKDVGSEGKHVRP 353

  Fly   212 ---AARGAGSIGSNSSQHGTSFTSVES--LRSDGEQTGGQQRAMTLPANARYGALPQGNSQGSHL 271
               ..:..|.:|..|...|......:.  |.|..|:||..|..|...:..: |.|......|...
Human   354 QIPGRKWGGFLGRRSKWDGPQNKKDKEGVLLSKAEKTGEPQTQMEKTSQVQ-GELGDDLRMGEKA 417

  Fly   272 HVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPR 336
            ..|.|.:..|....| .......|.......||       ||....:..|.|.....:|:.|   
Human   418 GELRSTTGKAGESWD-KKEKMGQPQGKSGNAGE-------ARSQTEKGCEAPKEVSTMVESP--- 471

  Fly   337 QLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTP 401
                                                    |.||.||     .||.|        
Human   472 ----------------------------------------AAPGKGG-----WPGSR-------- 483

  Fly   402 VGELPREIIIEMIRNSGEAVTVEVQPVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSAS 466
             |:...|........:| |:..|::             .||...:|:                .:
Human   484 -GQEAEEPCSRAGDGAG-ALETELE-------------GPSQPALEK----------------DA 517

  Fly   467 KRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADAS---QPERVWLVHRGGFTAAIRLP----TA 524
            :|.:.:..:::|....|||  || |...::|.|...   :.|:|||..:.|||.|..|.    ||
Human   518 ERPRIRKENQDGPAPQEEG--KG-GQSRDSDQAPEDRWYEAEKVWLAQKDGFTLATVLKPDEGTA 579

  Fly   525 S--SGRDEENKLSLRLLHNGEQ--LTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRY 585
            .  :||       :||..:.::  ..|||:.|.:.|.|.||.|||:..|..:||:|||:.|.|||
Human   580 DLPAGR-------VRLWIDADKTITEVDEEHVHRANPPELDQVEDLASLISVNESSVLNTLLQRY 637

  Fly   586 ASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSL 650
            .:.|:||..||.|:|:.|..|....:.||.   :| :.:.:|.|:.|:||.||.:|:..|||||:
Human   638 KAQLLHTCTGPDLIVLQPRGPSVPSAGKVP---KG-RRDGLPAHIGSMAQRAYWALLNQRRDQSI 698

  Fly   651 IFMGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLL 715
            :.:|.||:||:|..:..|.:|...||:.:..::.||:.|..|:|.|||:.....:.:|||.:.::
Human   699 VALGWSGAGKTTCCEQVLEHLVGMAGSVDGRVSVEKIRATFTVLRAFGSVSMAHSRSATRFSMVM 763

  Fly   716 SLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHP 780
            ||||:.||:|.:|.||.:|.|:.|..|:...|.:|.:.:::|||....|:.||:|..:.  ||..
Human   764 SLDFNATGRITAAQLQTMLLEKSRVARQPEGESNFLVFSQMLAGLDLDLRTELNLHQMA--DSSS 826

  Fly   781 F-ISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTART 844
            | :.:..|.||:.:||..|.:...|.|.|.|.....|.:|.:||||||||.||..|:|     |.
Human   827 FGMGVWSKPEDKQKAAAAFAQLQGAMEMLGISESEQRAVWRVLAAIYHLGAAGACKVG-----RK 886

  Fly   845 QFANPTAARKASGLLGVNLEDLSSAAF------------------GLTQPNAPNGGLSPSKSPTS 891
            ||.....|..|:..||...|:|::|.|                  ||......:|        ..
Human   887 QFMRFEWANYAAEALGCEYEELNTATFKHHLRQIIQQMTFGPSRWGLEDEETSSG--------LK 943

  Fly   892 DTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQNPASCGQQVGAT 956
            .||    .:|:|.:..|||.|..||||:||||...:...::||||::|:||||||...|:...||
Human   944 MTG----VDCVEGMASGLYQELFAAVVSLINRSFSSHHLSMASIMVVDSPGFQNPRHQGKDRAAT 1004

  Fly   957 LADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLISLIDKAPQNHVVRSS 1021
            ..:|.|||..||||:||:..|.|:...||.:|.|.::.|| .:..||..::::|:.|...|...:
Human  1005 FEELCHNYAHERLQLLFYQRTFVSTLQRYQEEGVPVQFDL-PDPSPGTTVAVVDQNPSQQVRLPA 1068

  Fly  1022 QRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDR----EHHSLLRKCAGPRQFVLHHL 1082
            ....:  |.||:.|:||||.....|:|...||||.:.:..:    |..|.||.|..|.|..:.|.
Human  1069 GGGAQ--DARGLFWVLDEEVHVEGSSDSVVLERLCAAFEKKGAGTEGSSALRTCEQPLQCEIFHQ 1131

  Fly  1083 QGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGT 1147
            .|.:||.|.:.||:..::.:....:|..:|..|.|||:..|:   ..|.....| |.:.||||||
Human  1132 LGWDPVRYDLTGWLHRAKPNLSALDAPQVLHQSKREELRSLF---QARAKLPPV-CRAVAGLEGT 1192

  Fly  1148 --QSLRRVSSIRRSFTT--AGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCY----LLQHNAGK 1204
              |:|:|...:||:|.:  |.|:|.:...|:|..:|.:...::|:..||:||.    :::..:|:
Human  1193 SQQALQRSRMVRRTFASSLAAVRRKAPCSQIKLQMDALTSMIKRSRLHFIHCLVPNPVVESRSGQ 1257

  Fly  1205 HTKYTANGSP---------SSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLL 1260
            .       ||         ..|.|.::     :::|.||.||.|..:|||.||||.|:.:.:.|.
Human  1258 E-------SPPPPQPGRDKPGAGGPLA-----LDIPALRVQLAGFHILEALRLHRTGYADHMGLT 1310

  Fly  1261 EFVRRFGLLAGDLAS---------NKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKR 1316
            .|.|:|.:|...|..         ::..:||::|...:|:..:..:|.||:..::||:|.||.:|
Human  1311 RFRRQFQVLDAPLLKKLMSTSEGIDERKAVEELLETLDLEKKAVAVGHSQVFLKAGVISRLEKQR 1375

  Fly  1317 DVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNV 1381
            :.|:|..|:..||.|:|:|:|::..:.:::.||.:|||:||..||||:|||||:||..:.|||:.
Human  1376 EKLVSQSIVLFQAACKGFLSRQEFKKLKIRRLAAQCIQKNVAVFLAVKDWPWWQLLGSLQPLLSA 1440

  Fly  1382 HRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKLEAKLSELTVDLAEERSTAHIATERLEA 1446
            ....|||:...|||..||.||||.|..|:|::.....||:|:::||.|||:||....:|.:.||:
Human  1441 TIGTEQLRAKEEELTTLRRKLEKSEKLRNELRQNTDLLESKIADLTSDLADERFKGDVACQVLES 1505

  Fly  1447 ETAERL--------------KLEKELGDQTNKVKNLQETTEKLEMELICAKSDLNGISEDEDAEN 1497
            |.||||              :::|:|||..   |.|:|..:|:::               .|.|.
Human  1506 ERAERLQAFREVQELKSKHEQVQKKLGDVN---KQLEEAQQKIQL---------------NDLER 1552

  Fly  1498 EDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQ 1562
            ....|...::::::....|.||.::||. |.|..|:..:..:|.||.||.:........:::..|
Human  1553 NPTGGADEWQMRFDCAQMENEFLRKRLQ-QCEERLDSELTARKELEQKLGELQSAYDGAKKMAHQ 1616

  Fly  1563 WKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAE-CQSLQDAVRQERQAKERYGREKDVL 1626
            .|||...:|.::.|..:|||.|.:||:.|||||:|||.: .|:|.::| .|:..:|:..:|...:
Human  1617 LKRKCHHLTCDLEDTCVLLENQQSRNHELEKKQKKFDLQLAQALGESV-FEKGLREKVTQENTSV 1680

  Fly  1627 QAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEM-----------TFGGGTEEEFAQLRRSKNE 1680
            :.|...|:|       .|:.||::.:.|::::|.:           :.|   |...|.|:....:
Human  1681 RWELGQLQQ-------QLKQKEQEASQLKQQVEMLQDHKRELLGSPSLG---ENCVAGLKERLWK 1735

  Fly  1681 TERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRGNGYKKIKAL 1745
            .|..|.||::...:....|:.|||.:.|.|:.:|.|::..:::.:.::||||:||.:..|::..|
Human  1736 LESSALEQQKIQSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELEDVRQSCQKRLHQL 1800

  Fly  1746 ECQLETEHEERTLLLREKHELERRLSSMEDR-DRVDRDAEEALNQKLRRDLRKYKALLKDAQTQL 1809
            |.|||.|:||:.::|.||.:||..:.::.|: ...|.|.|    ::||||||:..|||.|.|..|
Human  1801 EMQLEQEYEEKQMVLHEKQDLEGLIGTLCDQIGHRDFDVE----KRLRRDLRRTHALLSDVQLLL 1861

  Fly  1810 ERLKADTPGKTLI-----RQLRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEE 1869
            ..::   .|||.:     .::.:|||.:|:....|:|.::...|:|..:.:..:...|.::..:|
Human  1862 GTME---DGKTSVSKEELEKVHSQLEQSEAKCEEALKTQKVLTADLESMHSELENMTRNKSLVDE 1923

  Fly  1870 RANAAHRDRAELQAQIEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLKEQV 1934
            :......::|:|..:|:|::::|.|||:|:...:.|...:...:.|.:.:|.|.:.|::.|:||:
Human  1924 QLYRLQFEKADLLKRIDEDQDDLNELMQKHKDLIAQSAADIGQIQELQLQLEEAKKEKHKLQEQL 1988

  Fly  1935 AELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVT 1999
            ...|.|::.:|. .....|::| |.|....:||::.|.::....|.||.|.|.:::|.|:..|::
Human  1989 QVAQMRIEYLEQ-STVDRAIVS-RQEAVICDLENKTEFQKVQIKRFEVLVIRLRDSLIKMGEELS 2051

  Fly  2000 QSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLA 2064
            |:...|.|.::..:..|:.|.:::.:...:..||.|:..|..:|||.||::.:....|:.||..:
Human  2052 QAATSESQQRESSQYYQRRLEELKADMEELVQREAEASRRCMELEKYVEELAAVRQTLQTDLETS 2116

  Fly  2065 LQRIADLQQAMEE-------------------EGEEEL-------SESDESLSSVGS--ISDLED 2101
            ::||||||.|:||                   .|.:|:       |:.:.||.|..|  :|...|
Human  2117 IRRIADLQAALEEVASSDSDTESVQTAVDCGSSGRKEMDNVSILSSQPEGSLQSWLSCTLSLATD 2181

  Fly  2102 RLR-PVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVFEKDDNSPRITVTS---PSSPHIHK----- 2157
            .:| |.....:|.:.|:..|....|....:...:...:..::...:.||   |.|||..:     
Human  2182 TMRTPSRQSATSSRILSPRINEEAGDTERTQSALALSRARSTNVHSKTSGDKPVSPHFVRRQKYC 2246

  Fly  2158 -------LALAAKAIPANKPDTKPAAS--------TRMELTVPA 2186
                   ||:..|:....:|.:.|.||        :|.:|..|:
Human  2247 HFGDGEVLAVQRKSTERLEPASSPLASRSTNTSPLSREKLPSPS 2290

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 13/86 (15%)
MYSc 556..1317 CDD:214580 278/809 (34%)
MYSc_Myo18 575..1305 CDD:276837 263/778 (34%)
GBP_C <1540..1750 CDD:303769 65/221 (29%)
COG1340 1565..1833 CDD:224259 90/285 (32%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
MYO18BXP_011528760.1 Glutenin_hmw <114..542 CDD:281191 102/546 (19%)
MYSc 608..1376 CDD:214580 278/809 (34%)
MYSc_Myo18 627..1364 CDD:276837 263/778 (34%)
Smc 1457..>2133 CDD:224117 211/714 (30%)
GBP_C <1723..1818 CDD:303769 31/94 (33%)
coiled coil 1789..1803 CDD:293879 5/13 (38%)
RILP-like 1923..>2020 CDD:304877 26/98 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D23517at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41969
orthoMCL 1 0.900 - - OOG6_105087
Panther 1 1.100 - - LDO PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3038
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.820

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