DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and MYA2

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001190465.1 Gene:MYA2 / 834412 AraportID:AT5G43900 Length:1565 Species:Arabidopsis thaliana


Alignment Length:1745 Identity:375/1745 - (21%)
Similarity:660/1745 - (37%) Gaps:420/1745 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   504 PERVWL----VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVE 564
            |:..|:    |...|....:   ..:||:....|:|          .....|||   :||.. |:
plant    78 PDEAWIDGEVVQVNGDEIKV---LCTSGKHVVTKIS----------NAYPKDVE---APASG-VD 125

  Fly   565 DICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPL-SLYSEKVVSMFRGCKTEDMPP 628
            |:..|.||:|..||..|..||..|.|:|..|..|:.|||...| .|||..:::.::|....::.|
plant   126 DMTRLAYLHEPGVLQNLHSRYDINEIYTYTGSILIAVNPFRRLPHLYSSHMMAQYKGASLGELSP 190

  Fly   629 HVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAG--AYNNFINAEKVNALC 691
            |.:::|..|||.::.....||::..|.||:||:.|.|..:.|||...|  |.......:||....
plant   191 HPFAVADAAYRQMINDGVSQSILVSGESGAGKTESTKLLMRYLAYMGGRAAAEGRSVEQKVLESN 255

  Fly   692 TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRL 756
            .:||||||.||..|:|::|..:.:.:.||:.|:|:.|:::..|.||.|..:....|.::|....|
plant   256 PVLEAFGNAKTVRNNNSSRFGKFVEIQFDEKGRISGAAIRTYLLERSRVCQVSDPERNYHCFYML 320

  Fly   757 LAGAAGLLQKELHLENITSEDSHPFISLSQKLE-DRHRAANDFMRTVQAFETLNIDAKAVRGIWS 820
            .|..    |:::....:.....:.:::.|:.|| |....|.::..|.:|.:.:.|..:....|:|
plant   321 CAAP----QEDVKKFKLEEPKKYHYLNQSKCLELDSINDAEEYHATRRAMDVVGISTEEQDAIFS 381

  Fly   821 ILAAIYHLGIAGVTK-----LGTGSTARTQFANPTAARKASGLLGVN---LEDLSSAAFGLTQPN 877
            ::|||.|:|.....|     .......::.|...|||.    ||..:   |||.......:|:..
plant   382 VVAAILHIGNIEFAKGEEIDSSIPKDDKSLFHLKTAAE----LLSCDEKALEDSLCKRIMVTRDE 442

  Fly   878 APNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPG 942
            .....|.|..:..|          .:||...:||.....:|..||..|.....:...|.::|..|
plant   443 TITKTLDPEAATLS----------RDALAKVMYSRLFDWLVDKINSSIGQDHDSKYLIGVLDIYG 497

  Fly   943 FQN-PASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECHPGPLI 1006
            |:: ..:..:|....|.:       |:||..|:.......::.|.:|  ||............::
plant   498 FESFKTNSFEQFCINLTN-------EKLQQHFNQHVFKMEQEEYKKE--EINWSYIEFVDNQDIL 553

  Fly  1007 SLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRKC 1071
            .||:|.|                 .|::.||||..::|.|..:||.::|:..:  :.|....:..
plant   554 DLIEKKP-----------------GGIIALLDEACMFPRSTHETFAQKLYQTF--KTHKRFTKPK 599

  Fly  1072 AGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMV 1136
            .....|.:.|..|  .|.|..:.::..::::. |....:||..||..     ::.||        
plant   600 LARSDFTICHYAG--DVTYQTELFLDKNKDYV-IAEHQALLNSSSCS-----FVASL-------- 648

  Fly  1137 FCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHN 1201
                |..:.......:.|||...|              |..:..:::.|..|..|::.|.     
plant   649 ----FPPMSDDSKQSKFSSIGTRF--------------KQQLVSLLEILNTTEPHYIRCI----- 690

  Fly  1202 AGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRF 1266
                       .|::.......|.|.:     ..|||...|:||.|:...|:|......||:.||
plant   691 -----------KPNNLLKPGIFENENI-----LQQLRCGGVMEAIRISCAGYPTRKHFDEFLARF 739

  Fly  1267 GLLAGD-LASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRD------------- 1317
            |:||.: |..|.|........::::.:..|:||.:::..|:|.:::|:.:|.             
plant   740 GILAPEVLVKNSDDPAACKKLLDKVGLEGYQIGKTKVFLRAGQMADLDTRRTEVLGRSASIIQRK 804

  Fly  1318 ----------VLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDW-PWWRL 1371
                      ::|.:...|:|:.|||||||......| :|.|...|||:::.|||.:.: ..:..
plant   805 VRSYLAKKSFIVLRNSAKQIQSVCRGYLARSVYEGMR-REAAALKIQRDLRRFLARKAYTELYSA 868

  Fly  1372 LVRVTPLLN--VHRTEEQLKTANEELLMLRA------------KLEK----IECD-RSEV-KAEN 1416
            .|.|...:.  |.|.|...:...:..::::.            ||:|    .:|. ||:| :.|.
plant   869 AVSVQAGMRGMVARKELCFRRQTKAAIIIQTWCRGYLARLHYRKLKKAAITTQCAWRSKVARGEL 933

  Fly  1417 QKLEAKLSELTVDLAEERSTAHIATERLEAETAE---RLKLEKELG---DQTNKVKNLQETTEKL 1475
            :||:.        .|.|......|..:||.:..|   ||:|||.:.   ::..|.::.:..:...
plant   934 RKLKM--------AARETGALQAAKNKLEKQVEELTWRLQLEKRIRTDLEEAKKQESAKAQSSLE 990

  Fly  1476 EMELICAKSDLNGISEDEDAENEDGVGGGVYKL-KYERVARELEFTKRRLHTQHEHDLEQLVALK 1539
            |::|.|.:::...|.|.|.|:          |: :...:.:|:....:.|..:..::.|:|.::.
plant   991 ELQLKCKETEALLIKEREAAK----------KIAETAPIIKEIPVVDQELMDKITNENEKLKSMV 1045

  Fly  1540 KHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMND-LRMLLEEQNARNNLLEKKQRKFDAECQ 1603
            ..||||              :|:.::|.|:.|....| |...||        .|.|..|.....|
plant  1046 SSLEMK--------------IGETEKKLQETTKISQDRLNQALE--------AESKLVKLKTAMQ 1088

  Fly  1604 SLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEKLASLQRELEEMTFGGGT- 1667
            .|::.:..              ::|||..:.|....|.:.........|.: :.||.   |..| 
plant  1089 RLEEKILD--------------MEAEKKIMHQQTISTPVRTNLGHPPTAPV-KNLEN---GHQTN 1135

  Fly  1668 -EEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEEL 1731
             |:||       ||.|...     .:|..||                   :..|.|:....|..:
plant  1136 LEKEF-------NEAEFTT-----PVDGKAG-------------------KSAAERQIMNVDALI 1169

  Fly  1732 EEVRGN-GYKKIKAL------ECQLETEHEERTLLLREKHELERRL-----SSMEDRDRVDRDAE 1784
            :.|:.| |:...|.:      :|.|..:..|     .||..:..||     |::|:.|.      
plant  1170 DCVKDNIGFSNGKPVAAFTIYKCLLHWKCFE-----SEKTNVFDRLIQMIGSAIENEDD------ 1223

  Fly  1785 EALNQKLRRDLRKYKALL----------KDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLA 1839
               |..|...|....|||          ....||.::..|.|   :|..::......:.::.:||
plant  1224 ---NSHLAYWLTSTSALLFLLQKSLKTNGSGATQSKKPPAST---SLFGRMAMSFRSSPASGNLA 1282

  Fly  1840 MKARQTAEAELTEVQAMFD-----------------------------------ESHRARNDAEE 1869
            ..|...|.|.:..|:|.:.                                   ::.|:......
plant  1283 AAAEAAALAVVRPVEAKYPALLFKQQLAAYVEKMFGMVRDNLKRELSTLLSLCIQAPRSSKGGML 1347

  Fly  1870 RAN--------AAHRDRA-----ELQAQIEENEEELGELMKKYSATVKQLNTEQIN--------- 1912
            |:.        |.|....     .|...::||...|..:.|.||.|...:|.:..|         
plant  1348 RSGRSFGKDSPAVHWQSIIDGLNSLLVTLKENHVPLVLIQKIYSQTFSYINVQLFNSLLLRKECC 1412

  Fly  1913 -VSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRLELEQAT 1976
             .|..||           :|..:|||:......:....||.           :||:   .:.||.
plant  1413 TFSNGEF-----------VKSGLAELELWCCQAKEYSGPSW-----------EELK---HIRQAV 1452

  Fly  1977 RARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLRDMR---EEFHAVSSREQESLT 2038
            ...:..|  :::.:.:::.|::..           :...|:..|...   ::.:...|..||.::
plant  1453 GFLVIHQ--KYRISYDEIANDLCP-----------VLSVQQLYRICTLYWDDSYNTRSVSQEVIS 1504

  Fly  2039 RRKDL-EKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSS 2092
            ..:.| .::....:|:...|.:|..:... |.|:..:|||:....:..::|.|.:
plant  1505 SMRTLMTEESNDADSDSFLLDDDSSIPFS-IDDISSSMEEKDFVGIKPAEELLEN 1558

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 189/774 (24%)
MYSc_Myo18 575..1305 CDD:276837 178/743 (24%)
GBP_C <1540..1750 CDD:303769 44/219 (20%)
COG1340 1565..1833 CDD:224259 59/292 (20%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
MYA2NP_001190465.1 Myosin_N 73..108 CDD:280832 6/32 (19%)
MYSc 117..790 CDD:214580 191/777 (25%)
MYSc_Myo11 136..779 CDD:276835 178/743 (24%)
IQ 889..911 CDD:197470 0/21 (0%)
RILP-like 964..1083 CDD:304877 31/150 (21%)
MyosinXI_CBD 1159..1535 CDD:271259 72/431 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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