DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and PDZD7

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	NP_001182192.1	Gene:	PDZD7 / 79955	HGNCID:	26257	Length:	1033	Species:	Homo sapiens

Alignment Length:	918	Identity:	180/918 - (19%)
Similarity:	278/918 - (30%)	Gaps:	312/918 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 GAGSIGSNSSQHGTSFTSVESLRSDGEQTG------GQQRAMTLPANARYGALPQGNSQGSHLHV 273
            |.|.:.|.|.   :|.:|...|.||...|.      .|||.:..|......:.|.|     .:.:
Human    13 GLGDLSSGSL---SSLSSRGHLGSDSGSTATRYLLRKQQRLLNGPPRGIRASSPMG-----RVIL 69

  Fly   274 LTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQL 338
            :.||..:....:|..:|
Human    70 INSPIEANSDESDIIHS------------------------------------------------ 86

  Fly   339 VIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNG---- 399
             :|.:|||....|||:|..      ......||  |...|.|:.....||..||::.:|||
Human    87 -VRVEKSPAGRLGFSVRGG------SEHGLGIF--VSKVEEGSSAERAGLCVGDKITEVNGLSLE 142

  Fly   400 -TPVGELPREI-----IIEMIRNSG--------EAVTVEVQPVAELVELSKRCMAPSTATVEE-- 448
             |.:|...:.:     :..|:|..|        :..|..|..|...:.:.|....||..:.|:
Human   143 STTMGSAVKVLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSSEDGV 207

  Fly   449 --IDHSITNGN--CNTLRRSASKRFK---RQSRHENGNGGGEEGGAKGVGHDLEA-------DVA 499
              |.|..|..:  |........|.|.   ..|:.::| |..||.|.| ||..:.|       |::
Human   208 RRIVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHG-GLAEENGIK-VGDQVLAANGVRFDDIS 270

  Fly   500 DASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVE 564
            .:...|    |.:|  ...|.|....:||....|                           ::|.
Human   271 HSQAVE----VLKG--QTHIMLTIKETGRYPAYK---------------------------EMVS 302

  Fly   565 DICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPH 629
            :.|.|..|:..                        |:..::|.|..|..|.|    |.
Human   303 EYCWLDRLSNG------------------------VLQQLSPASESSSSVSS----CA------- 332

  Fly   630 VYSLAQTAYRSLVETRRDQSLIFMGRS-------GSGKSTSFKHALNYLALAAGAYNNFINAEKV 687
              |.|..:..||...|.|   |.:|:.       |.|::.:   |:.....|.|         :|
Human   333 --SSAPYSSGSLPSDRMD---ICLGQEEPGSRGPGWGRADT---AMQTEPDAGG---------RV 380

  Fly   688 NALCTILEAFGNTKTCLNSN--------------ATRMTQLLSLDFDQTGQIASASLQVLLPER- 737
            ...|::........|.:.|:              :.:...||:|...:.....|.|...|..|:
Human   381 ETWCSVRPTVILRDTAIRSDGPHPGRRLDSALSESPKTALLLALSRPRPPITRSQSYLTLWEEKQ 445

  Fly   738 QRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAANDFMRTV 802
            ||...:.|.           .|..|.||:...|.|:..:...           :.|.|.|..|
Human   446 QRKKEKSGS-----------PGEKGALQRSKTLMNLFFKGGR-----------QGRLARDGRR-- 486

  Fly   803 QAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLS 867
               |...:|:.::...:..|......|:..|.|..|....|.|       .:...||
Human   487 ---EAWTLDSGSLAKTYPRLDIEKAGGVGPVQKFVTWRLRRDQ-------ERGRALL-------- 533

  Fly   868 SAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTI 932
            ||..|           |||....:......|||....|:                       ..:
Human   534 SARSG-----------SPSSQLPNVDEQVQAWESRRPLI-----------------------QDL 564

  Fly   933 ASIMLIDTPGFQNPASCGQQV-GATLADLRHNYL-----QERLQMLFHHTTLVAPRD--RYAQEL 989
            |..:|.|.........|.:.| ...:.||....|     .|:|.:|....::|||.|  |:...:
Human   565 AQRLLTDDEVLAVTRHCSRYVHEGGIEDLVRPLLAILDRPEKLLLLQDIRSVVAPTDLGRFDSMV 629

  Fly   990 VEIEMD----LASECHPGPLI--SLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSND 1048
            :.:|::    |.|.....|.:  :..|..|:.|::....      |.||..:||.... :|...|
Human   630 MLVELEAFEALKSRAVRPPALRPARQDTPPKRHLITPVP------DSRGGFYLLPVNG-FPEEED 687

  Fly  1049 DTFL-ERL 1055
            :..| |||
Human   688 NGELRERL 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	26/104 (25%)
		MYSc	556..1317	CDD:214580	103/537 (19%)
		MYSc_Myo18	575..1305	CDD:276837	99/518 (19%)
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
PDZD7	NP_001182192.1	PDZ_signaling	84..164	CDD:238492	24/136 (18%)
		PDZ_signaling	209..289	CDD:238492	22/87 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..380		17/84 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		7/30 (23%)
		HN_PDZD7_like	554..630	CDD:259824	19/98 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..864
		PDZ_signaling	860..948	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..1033
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900